Loghmari Ahmed, Bouassida Khaireddine, Belkacem Oussama, Othmane Mouna Ben, Hmida Wissem, Jaidane Mehdi
Urology Department, Sahloul Hospital, Sousse, Tunisia.
Pathology Department, Sahloul Hospital, Sousse, Tunisia.
Int J Surg Case Rep. 2020;77:392-396. doi: 10.1016/j.ijscr.2020.11.003. Epub 2020 Nov 4.
Encrusted cystitis and Encrusted pyelitis are rare chronic inflammatory diseases. Those conditions are commonly caused by the Corynebacterium spp. especially the type D2 which is a gram positive, aerobic, slow-growing, and urea-sliting bacteria with a multi-antibiotic resistant profile.
We report the case of a 62-year-old man with a past history of chronic obstructive pulmonary disease. He was referred to the department of urology for urosepsis. Bacterial culture results were positive to Corynebacterium urealyticum. The diagnosis of encrusted cystitis and pyelitis were highly considered. An adapted antibiotherapy was undertaken using vancomycin during 3 weeks. The patient presented two acute peritonitis : the first was caused by a spontaneous bladder dome rupture which was surgically repaired and the second was caused by a total bladder rupture which required cysto-prostatectomy and bilateral ureterostomy. The post operative outcomes were uneventful. Bacterial urinalysis was negative and total recovery was obtained.
In the majority of the reported cases, there were no sepsis or peritonitis conditions. Medical treatment by the glycopeptides and urine acidification was sufficient. However in this case, the sepsis condition and the bladder rupture with acute peritonitis made exclusively medical treatment by antibiotics insufficient. Therefore cystectomy associated to conventional antibiotics were able to limit the systemic dissemination of the bacteria and save the patient's life.
Glycopeptides antibiotics are currently the preferential treatment of encrusted cystitis. In some complicated conditions such as bladder rupture and urosepsis as in this case, radical surgical treatment by cystectomy must be realized early to avoid peritonea and septic shock.
结痂性膀胱炎和结痂性肾盂炎是罕见的慢性炎症性疾病。这些病症通常由棒状杆菌属引起,尤其是D2型,它是一种革兰氏阳性、需氧、生长缓慢且具有多重抗生素耐药性的尿素分解菌。
我们报告一例62岁男性,有慢性阻塞性肺疾病病史。他因尿脓毒症被转诊至泌尿外科。细菌培养结果显示解脲棒状杆菌呈阳性。高度怀疑为结痂性膀胱炎和肾盂炎。采用万古霉素进行了为期3周的适应性抗菌治疗。该患者出现了两次急性腹膜炎:第一次是由自发性膀胱穹窿破裂引起,通过手术修复;第二次是由膀胱全层破裂引起,需要进行膀胱前列腺切除术和双侧输尿管造口术。术后恢复顺利。细菌尿分析呈阴性,患者完全康复。
在大多数已报道的病例中,不存在脓毒症或腹膜炎情况。使用糖肽类药物进行药物治疗和尿液酸化就足够了。然而在本病例中,脓毒症情况以及伴有急性腹膜炎的膀胱破裂使得仅用抗生素进行药物治疗是不够的。因此,膀胱切除术联合传统抗生素能够限制细菌的全身播散并挽救患者生命。
糖肽类抗生素目前是结痂性膀胱炎的首选治疗方法。在某些复杂情况下,如本病例中的膀胱破裂和尿脓毒症,必须尽早进行膀胱切除术等根治性手术治疗,以避免腹膜炎和感染性休克。