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1
Human calcitonin gene-related peptide activates adenylate cyclase and releases prostacyclin from human umbilical vein endothelial cells.人降钙素基因相关肽激活腺苷酸环化酶并从人脐静脉内皮细胞释放前列环素。
Br J Pharmacol. 1987 Dec;92(4):695-701. doi: 10.1111/j.1476-5381.1987.tb11373.x.
2
Calcitonin gene related peptide (CGRP) activates adenylate cyclase of bovine aortic endothelial cells: guanosine 5' triphosphate dependence and partial agonist activity of a tyrosinated analogue.降钙素基因相关肽（CGRP）激活牛主动脉内皮细胞的腺苷酸环化酶：鸟苷5'-三磷酸依赖性及一种酪氨酸化类似物的部分激动剂活性。
Cardiovasc Res. 1989 Nov;23(11):921-7. doi: 10.1093/cvr/23.11.921.
3
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Am J Physiol. 1989 Feb;256(2 Pt 1):E331-5. doi: 10.1152/ajpendo.1989.256.2.E331.
4
Action of calcitonin gene-related peptide upon bovine vascular endothelial and smooth muscle cells grown in isolation and co-culture.降钙素基因相关肽对单独培养及共培养的牛血管内皮细胞和平滑肌细胞的作用。
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5
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7
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8
Neurotensin induces the release of prostacyclin from human umbilical vein endothelial cells in vitro and increases plasma prostacyclin levels in the rat.神经降压素在体外可诱导人脐静脉内皮细胞释放前列环素，并能提高大鼠血浆中前列环素的水平。
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10
Photoaffinity labeling of rat calcitonin gene-related peptide receptors and adenylate cyclase activation: identification of receptor subtypes.大鼠降钙素基因相关肽受体的光亲和标记与腺苷酸环化酶激活：受体亚型的鉴定
Endocrinology. 1993 Feb;132(2):744-50. doi: 10.1210/endo.132.2.8381072.

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7
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8
Identification of a protein that confers calcitonin gene-related peptide responsiveness to oocytes by using a cystic fibrosis transmembrane conductance regulator assay.通过使用囊性纤维化跨膜传导调节因子检测法鉴定一种赋予卵母细胞降钙素基因相关肽反应性的蛋白质。
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9
Regulation of tone in penile cavernous smooth muscle. Established concepts and new findings.阴茎海绵体平滑肌张力的调节。既定概念与新发现。
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10
Action of calcitonin gene-related peptide upon bovine vascular endothelial and smooth muscle cells grown in isolation and co-culture.降钙素基因相关肽对单独培养及共培养的牛血管内皮细胞和平滑肌细胞的作用。
Br J Pharmacol. 1990 Jan;99(1):71-6. doi: 10.1111/j.1476-5381.1990.tb14656.x.

本文引用的文献

1
Isolation and characterization of human calcitonin gene-related peptide.人降钙素基因相关肽的分离与鉴定
Nature. 1984;308(5961):746-8. doi: 10.1038/308746a0.
2
Stimulation of noradrenergic sympathetic outflow by calcitonin gene-related peptide.降钙素基因相关肽对去甲肾上腺素能交感神经传出的刺激作用。
Nature. 1983;305(5934):534-6. doi: 10.1038/305534a0.
3
Prostaglandin I2 is not a major metabolite of arachidonic acid in cultured endothelial cells from human foreskin microvessels.前列腺素I2并非来自人包皮微血管的培养内皮细胞中花生四烯酸的主要代谢产物。
J Clin Invest. 1984 Sep;74(3):914-9. doi: 10.1172/JCI111509.
4
Stimulation of endothelial prostacyclin production plays no role in endothelium-dependent relaxation of the pig aorta.刺激内皮前列环素生成在猪主动脉内皮依赖性舒张中不起作用。
Br J Pharmacol. 1983 Sep;80(1):179-86. doi: 10.1111/j.1476-5381.1983.tb11064.x.
5
Arachidonic acid and prostaglandin endoperoxide metabolism in isolated rabbit and coronary microvessels and isolated and cultivated coronary microvessel endothelial cells.花生四烯酸和前列腺素内过氧化物在离体兔冠状动脉微血管以及离体培养的冠状动脉微血管内皮细胞中的代谢
J Clin Invest. 1983 Nov;72(5):1658-71. doi: 10.1172/JCI111125.
6
Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing.通过组织特异性RNA加工产生由降钙素基因编码的一种新型神经肽。
Nature. 1983;304(5922):129-35. doi: 10.1038/304129a0.
7
The myotropic and plasma-calcium modulating effects of calcitonin gene-related peptide (CGRP).降钙素基因相关肽（CGRP）的亲肌性及血浆钙调节作用。
Neuropeptides. 1984 Sep;4(5):425-34. doi: 10.1016/0143-4179(84)90118-5.
8
Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products.降钙素基因表达过程中的可变RNA加工产生编码不同多肽产物的mRNA。
Nature. 1982 Jul 15;298(5871):240-4. doi: 10.1038/298240a0.
9
A highly sensitive adenylate cyclase assay.一种高灵敏度的腺苷酸环化酶检测方法。
Anal Biochem. 1974 Apr;58(2):541-8. doi: 10.1016/0003-2697(74)90222-x.
10
Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria.源自脐静脉的人内皮细胞培养。通过形态学和免疫学标准进行鉴定。
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人降钙素基因相关肽激活腺苷酸环化酶并从人脐静脉内皮细胞释放前列环素。

Human calcitonin gene-related peptide activates adenylate cyclase and releases prostacyclin from human umbilical vein endothelial cells.

作者信息

Crossman D, McEwan J, MacDermot J, MacIntyre I, Dollery C T

机构信息

Department of Clinical Pharmacology, Royal Postgraduate Medical School, London.

出版信息

Br J Pharmacol. 1987 Dec;92(4):695-701. doi: 10.1111/j.1476-5381.1987.tb11373.x.

DOI:10.1111/j.1476-5381.1987.tb11373.x
PMID:3322463
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1853704/
Abstract

1 Endothelial cells of human umbilical vein were isolated and cultured in vitro. 2 In these cells there was a concentration-dependent release of prostacyclin and activation of adenylate cyclase by human calcitonin gene-related peptide (hCGRP). The concentration of hCGRP for half-maximum activation of adenylate cyclase (Kact) by hCGRP was 190 nM. 3 Bradykinin induced a ten fold greater release of prostacyclin than CGRP, but did not activate adenylate cyclase. 4 hCGRP may exert its potent vasodilator properties by stimulating release of vasorelaxant substances, including prostacyclin from endothelial cells.

摘要
  1. 人脐静脉内皮细胞被分离并在体外培养。2. 在这些细胞中，人降钙素基因相关肽（hCGRP）可引起前列环素浓度依赖性释放及腺苷酸环化酶激活。hCGRP激活腺苷酸环化酶的半数最大激活浓度（Kact）为190 nM。3. 缓激肽诱导的前列环素释放比CGRP大10倍，但不激活腺苷酸环化酶。4. hCGRP可能通过刺激包括内皮细胞前列环素在内的血管舒张物质释放而发挥其强大的血管舒张特性。