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新型耐药结核病 6 个月疗程，美国。

Novel 6-Month Treatment for Drug-Resistant Tuberculosis, United States.

出版信息

Emerg Infect Dis. 2021 Jan;27(1):332-4. doi: 10.3201/eid2701.203766. Epub 2020 Nov 23.

DOI:10.3201/eid2701.203766
PMID:33227229
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7774582/
Abstract

The US Food and Drug Administration approved a 6-month regimen of pretomanid, bedaquiline, and linezolid for extensively drug-resistant or multidrug-intolerant tuberculosis after a trial in South Africa demonstrated 90% effectiveness 6 months posttreatment. We report on a patient who completed the regimen using a lower linezolid dose.

摘要

美国食品和药物管理局批准了一种为期 6 个月的普托马尼德、贝达喹啉和利奈唑胺治疗方案，用于广泛耐药或耐多药结核病，此前南非的一项试验显示，治疗后 6 个月的有效率为 90%。我们报告了一位使用较低剂量利奈唑胺完成该方案的患者。

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本文引用的文献

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Primary Clofazimine and Bedaquiline Resistance among Isolates from Patients with Multidrug-Resistant Tuberculosis.耐多药结核病患者分离株中对氯法齐明和贝达喹啉的原发性耐药情况。
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The Role of Therapeutic Drug Monitoring in Mycobacterial Infections.治疗药物监测在分枝杆菌感染中的作用。
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Linezolid Trough Concentrations Correlate with Mitochondrial Toxicity-Related Adverse Events in the Treatment of Chronic Extensively Drug-Resistant Tuberculosis.利奈唑胺谷浓度与慢性广泛耐药结核病治疗中与线粒体毒性相关的不良事件相关。
EBioMedicine. 2015 Oct 9;2(11):1627-33. doi: 10.1016/j.ebiom.2015.09.051. eCollection 2015 Nov.
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Preclinical Evaluations To Identify Optimal Linezolid Regimens for Tuberculosis Therapy.用于确定结核病治疗最佳利奈唑胺方案的临床前评估
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Linezolid for treatment of chronic extensively drug-resistant tuberculosis.利奈唑胺治疗慢性广泛耐药结核病。
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