NuGut Research Platform, School of Nutrition Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada.
NuGut Research Platform, School of Nutrition Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada; Department of Microbiology and Immunology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
Prog Neuropsychopharmacol Biol Psychiatry. 2021 Jun 8;108:110182. doi: 10.1016/j.pnpbp.2020.110182. Epub 2020 Nov 21.
Emerging evidence highlighted the essential role played by the microbiota-gut-brain axis in maintaining human homeostasis, including nutrition, immunity, and metabolism. Much recent work has linked the gut microbiota to many psychiatric and neurodegenerative disorders such as depression, schizophrenia, and Alzheimer's disease. Shared gut microbiota alterations or dysbiotic microbiota have been identified in these separate disorders relative to controls. Much attention has focused on the bidirectional interplay between the gut microbiota and the brain, establishing gut dysbiotic status as a critical factor in psychiatric disorders. Still, the antibiotic-like effect of psychotropic drugs, medications used for the treatment of these disorders, on gut microbiota is largely neglected. In this review, we summarize the current findings on the impact of psychotropics on gut microbiota and how their antimicrobial potency can trigger dysbiosis. We also discuss the potential therapeutic strategies, including probiotics, prebiotics, and fecal transplantation, to attenuate the dysbiosis related to psychotropics intake.
新出现的证据强调了微生物群-肠道-大脑轴在维持人类体内平衡方面的重要作用，包括营养、免疫和代谢。最近的大量研究将肠道微生物群与许多精神疾病和神经退行性疾病联系起来，如抑郁症、精神分裂症和阿尔茨海默病。与对照组相比，这些不同的疾病中都发现了肠道微生物群的改变或失调。人们非常关注肠道微生物群和大脑之间的双向相互作用，将肠道失调状态确立为精神疾病的一个关键因素。尽管如此，抗精神病药物（用于治疗这些疾病的药物）对肠道微生物群的抗生素样作用在很大程度上仍被忽视。在这篇综述中，我们总结了精神药物对肠道微生物群的影响的最新发现，以及它们的抗菌效力如何引发失调。我们还讨论了潜在的治疗策略，包括益生菌、益生元和粪便移植，以减轻与精神药物摄入相关的失调。
