Zhang Yangbo, Lin Yong, Xiong Yifan, Huang Jianan, Liu Zhonghua
School of Pharmacy, Shaoyang University, Shaoyang 422000, China.
Key Laboratory of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha 410128, China.
Foods. 2024 Aug 22;13(16):2636. doi: 10.3390/foods13162636.
Recently, research has confirmed that jasmine tea may help improve the depressive symptoms that are associated with psychiatric disorders. Our team previously found that jasmine tea improved the depressive-like behavior that is induced by chronic unpredictable mild stress (CUMS) in Sprague Dawley (SD) rats. We hypothesized that the metabolic disorder component of depression may be related to the gut microbiota, which may be reflected in the metabolome in plasma. The influence of jasmine tea on gut microbiota composition and the association with depressive-related indexes were explored. Furthermore, the metabolites in plasma that are related to the gut microbiota were identified. SD rats were treated with control or CUMS and administrated jasmine tea for 8 weeks. The 16S rRNA gene amplicon sequencing was used to analyze the gut microbiota in feces samples, and untargeted metabolomics was used to analyze the metabolites in plasma. The results found that jasmine tea significantly ameliorated the depressive behavior induced by CUMS, significantly improved the neurotransmitter concentration (BDNF and 5-HT), and decreased the pro-inflammation levels (TNF-α and NF-κB). The intervention of jasmine tea also alleviated the dysbiosis caused by CUMS; increased the relative abundance of and ; and decreased and in the CUMS-treated rats. Furthermore, the serum metabolites of the CUMS-treated rats were reversed after the jasmine tea intervention, i.e., 22 were up-regulated and 18 were down-regulated, which may have a close relationship with glycerophospholipid metabolism pathways, glycine serine and threonine metabolism pathways, and nicotinate and nicotinamide metabolism pathways. Finally, there were 30 genera of gut microbiota related to the depressive-related indexes, and 30 metabolites in the plasma had a strong predictive ability for depressive behavior. Potentially, our research implies that the intervention of jasmine tea can ameliorate the depression induced by CUMS via controlling the gut flora and the host's metabolism, which is an innovative approach for the prevention and management of depression.
最近，研究证实茉莉花茶可能有助于改善与精神疾病相关的抑郁症状。我们的团队之前发现，茉莉花茶改善了慢性不可预测轻度应激（CUMS）诱导的Sprague Dawley（SD）大鼠的抑郁样行为。我们假设抑郁症的代谢紊乱成分可能与肠道微生物群有关，这可能反映在血浆代谢组中。探讨了茉莉花茶对肠道微生物群组成的影响及其与抑郁相关指标的关联。此外，还鉴定了与肠道微生物群相关的血浆代谢物。将SD大鼠分为对照组或接受CUMS处理，并给予茉莉花茶8周。采用16S rRNA基因扩增子测序分析粪便样本中的肠道微生物群，采用非靶向代谢组学分析血浆中的代谢物。结果发现，茉莉花茶显著改善了CUMS诱导的抑郁行为，显著提高了神经递质浓度（BDNF和5-HT），并降低了促炎水平（TNF-α和NF-κB）。茉莉花茶的干预还缓解了CUMS引起的肠道菌群失调；增加了 和 的相对丰度；并降低了CUMS处理大鼠中 和 的水平。此外，茉莉花茶干预后，CUMS处理大鼠的血清代谢物发生了逆转，即22种上调，18种下调，这可能与甘油磷脂代谢途径、甘氨酸丝氨酸和苏氨酸代谢途径以及烟酸和烟酰胺代谢途径密切相关。最后，有30种肠道微生物群属与抑郁相关指标有关，血浆中的30种代谢物对抑郁行为具有较强的预测能力。我们的研究可能意味着，茉莉花茶的干预可以通过控制肠道菌群和宿主代谢来改善CUMS诱导的抑郁症，这是一种预防和管理抑郁症的创新方法。
