Zhang Yangbo, Liu Changwei, Zhu Qi, Wu Hui, Liu Zhonghua, Zeng Li
School of Pharmacy, Shaoyang University, Shaoyang 422000, China.
Key Laboratory of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha 410128, China.
Nutrients. 2025 Jan 12;17(2):259. doi: 10.3390/nu17020259.
Depression, a serious mental illness, is characterized by high risk, high incidence, persistence, and tendency to relapse, posing a significant burden on global health. The connection between depression and gut microbiota is an emerging field of study in psychiatry and neuroscience. Understanding the gut-brain axis is pivotal for understanding the pathogenesis and treatment of depression. Gut microbes influence depression-like behaviors by impacting the hypothalamic-pituitary-adrenal axis (HPA), monoamine neurotransmitters, immune responses, cell signaling, and metabolic pathways. Tea, widely used in clinical practice to improve neuropsychiatric disorders, contains Epigallocatechin gallate (EGCG), a major ingredient of green tea, which effectively regulates intestinal flora. This review examined the risks and causes of depression, the complications associated with intestinal flora, their role in the development and treatment of depression, and how EGCG may alleviate depression through interactions with gut microbiota and other mechanisms.
抑郁症是一种严重的精神疾病，具有高风险、高发病率、持续性和复发倾向，给全球健康带来了重大负担。抑郁症与肠道微生物群之间的联系是精神病学和神经科学中一个新兴的研究领域。了解肠-脑轴对于理解抑郁症的发病机制和治疗至关重要。肠道微生物通过影响下丘脑-垂体-肾上腺轴（HPA）、单胺类神经递质、免疫反应、细胞信号传导和代谢途径来影响类似抑郁的行为。茶在临床实践中广泛用于改善神经精神疾病，其中含有表没食子儿茶素没食子酸酯（EGCG），它是绿茶的主要成分，能有效调节肠道菌群。这篇综述探讨了抑郁症的风险和病因、与肠道菌群相关的并发症、它们在抑郁症发生和治疗中的作用，以及EGCG如何通过与肠道微生物群的相互作用和其他机制来缓解抑郁症。
