Department of Ophthalmology, Mugla Sitki Kocman University School of Medicine, Mugla, Turkey.
Department of Ophthalmology, Mugla Sitki Kocman Education and Training Hospital, Mugla, Turkey.
Eye (Lond). 2021 Oct;35(10):2719-2726. doi: 10.1038/s41433-020-01294-z. Epub 2020 Nov 24.
The aim of this study was to evaluate the perifoveal and peripapillary microvascular structure in patients with Behçet's disease (BD) without clinically ocular involvement.
Fifty-six eyes of 28 patients with Behçet's disease without clinically ocular involvement and 50 age-matched healthy eyes were included in this prospective study. Vessel densities (VD) of macula and optic nerve head, foveal avascular zone (FAZ), choroid capillary plexus (CCP) flow area, perifoveal capillary nonperfusion, capillary dilatation and/or telangiectasia and perifoveal capillary arcade disruption were analyzed with optical coherence tomography angiography (OCTA). The relationship between duration of disease and vessel densities was also evaluated.
The FAZ was significantly higher in the BD group (p < 0.001). VD of the foveal and parafoveal region in deep capillary plexus (DCP) were significantly lower in the BD group than in the control group (p < 0.001, p < 0.001). Total disc, peripapillary and inside-disc VD were significantly lower in BD group (p = 0.001, p = 0.002, p = 0.004). Perifoveal morphological changes in DCP were significantly higher in nonocular BD (p < 0.001, p < 0.001, p < 0.001). There was a mild negative correlation between disease duration and whole VD in DCP, total disc VD, peripapillary VD was determined (For whole VD in DCP, r = -0.400, p = 0.035; for total disc VD r = -0.396, p = 0.037; for peripapillary VD r = -0.442, p = 0.018).
Perifoveal and peripapillary microvascular changes that can be detected by OCTA may occur in Behçet's patients without clinically ocular involvement.
本研究旨在评估无临床眼部受累的贝赫切特病（BD）患者的周边黄斑和视盘微血管结构。
本前瞻性研究纳入了 28 例无临床眼部受累的贝赫切特病患者的 56 只眼和 50 名年龄匹配的健康对照者。使用光学相干断层扫描血管造影（OCTA）分析黄斑和视盘神经头血管密度（VD）、中心凹无血管区（FAZ）、脉络膜毛细血管丛（CCP）血流面积、周边黄斑无灌注、毛细血管扩张和/或毛细血管扩张和周边黄斑弓状血管破坏。还评估了疾病持续时间与血管密度之间的关系。
BD 组 FAZ 明显较高（p<0.001）。BD 组的深层毛细血管丛（DCP）中黄斑和旁黄斑区的 VD 明显低于对照组（p<0.001，p<0.001）。BD 组视盘总面积、视盘周围和视盘内 VD 明显低于对照组（p=0.001，p=0.002，p=0.004）。非眼部 BD 患者的 DCP 周边形态学改变明显较高（p<0.001，p<0.001，p<0.001）。DCP 全 VD、视盘总面积 VD、视盘周围 VD 与疾病持续时间呈轻度负相关（DCP 全 VD，r=-0.400，p=0.035；视盘总面积 VD，r=-0.396，p=0.037；视盘周围 VD，r=-0.442，p=0.018）。
无临床眼部受累的贝赫切特病患者可能出现 OCTA 可检测到的周边黄斑和视盘微血管变化。
