Bengtsen Maria Bisgaard, Heide-Jørgensen Uffe, Blichert-Refsgaard Linea Sandfeld, Hjelholt Thomas Johannesson, Borre Michael, Nørgaard Mette
Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark.
Department of Urology, Aarhus University Hospital, Aarhus N, Denmark.
Clin Epidemiol. 2020 Nov 16;12:1281-1285. doi: 10.2147/CLEP.S278554. eCollection 2020.
Benign prostatic hyperplasia comprises a significant burden to ageing men due to frequently associated lower urinary tract symptoms and the risk of developing serious complications, such as acute urinary retention. Healthcare databases are a valuable source of epidemiological research; however, continuous validation of definitions is imperative. We examined the positive predictive values of International Classification of Diseases, 10th Revision (ICD-10), diagnostic coding for benign prostatic hyperplasia and acute urinary retention in men in the Danish National Patient Registry.
We investigated a random sample of 100 men diagnosed with benign prostatic hyperplasia and 100 men diagnosed with acute urinary retention between 2011 and 2017 in the Central Denmark Region. Using medical record review as reference standard, we estimated the positive predictive value with corresponding 95% confidence intervals (CI) overall and stratified by age, type of hospital (university hospital vs regional hospital), type of hospital contact (inpatient, outpatient or emergency room), calendar year group (2011-2013, 2014-2017), and department (department of urology, geriatrics, endocrinology or emergency room).
Medical records were available for all 200 sampled patients. We found an overall positive predictive value (PPV) of 95% (95% CI: 89-98%) for benign prostatic hyperplasia and 98% (95% CI: 93-99%) for acute urinary retention. The PPVs were consistent across age, type of hospital, type of hospital contact, calendar year group, and department.
The PPVs of ICD-10 codes for benign prostatic hyperplasia and acute urinary retention recorded in the Danish National Patient Registry are high.
良性前列腺增生给老年男性带来了沉重负担，因为其常伴有下尿路症状，且存在发生严重并发症（如急性尿潴留）的风险。医疗保健数据库是流行病学研究的宝贵资源；然而，对定义进行持续验证至关重要。我们在丹麦国家患者登记处研究了国际疾病分类第十版（ICD - 10）对男性良性前列腺增生和急性尿潴留诊断编码的阳性预测值。
我们调查了2011年至2017年期间在丹麦中部地区被诊断为良性前列腺增生的100名男性和被诊断为急性尿潴留的100名男性的随机样本。以病历审查作为参考标准，我们总体上并按年龄、医院类型（大学医院与地区医院）、医院接触类型（住院、门诊或急诊室）、日历年组（2011 - 2013年、2014 - 2017年）以及科室（泌尿外科、老年医学科、内分泌科或急诊室）分层，估计了阳性预测值及相应的95%置信区间（CI）。
所有200名抽样患者的病历均可用。我们发现良性前列腺增生的总体阳性预测值（PPV）为95%（95%CI：89 - 98%），急性尿潴留的为98%（95%CI：93 - 99%）。PPV在年龄、医院类型、医院接触类型、日历年组和科室之间是一致的。
丹麦国家患者登记处记录的ICD - 10编码对良性前列腺增生和急性尿潴留的PPV很高。
