Batista-Miranda Jose E, Molinuevo Beatriz, Pardo Yolanda
Urodynamics Unit, CM Teknon, Barcelona, Spain.
Urology. 2007 Feb;69(2):285-8. doi: 10.1016/j.urology.2006.09.054.
To assess the impact of lower urinary tract symptoms (LUTS) on general quality-of-life (QOL) measures in an outpatient setting.
A total of 1546 male patients aged 51 years or older and scoring more than 11 in the International Prostate Symptom Score completed the general version of the Functional Assessment Cancer Therapy, the Benign Prostatic Hyperplasia Impact Index, and additional questions. Previous prostatic surgery and neurourologic conditions were exclusion criteria, but the use of urologic medication was not.
LUTS and QOL were significantly related to age, with older patients presenting with more symptoms and worse QOL. In addition, the results showed negative correlations between LUTS and QOL. The division of the severity groups according to the International Prostate Symptom Score showed that patients from the severe group reported significantly worse QOL compared with the moderate group. The 32% variance in the FACT-G was explained by the International Prostate Symptom Score items, controlling for age. Nocturia combined with incomplete bladder emptying were the strongest predictors of QOL.
LUTS have considerable impact on the general well-being of the patient. Combined with age, they can explain up to 30% of the variance in QOL. Nocturia and incomplete emptying are the most troublesome symptoms.
评估门诊环境下下尿路症状（LUTS）对总体生活质量（QOL）指标的影响。
共有1546名年龄在51岁及以上、国际前列腺症状评分超过11分的男性患者完成了癌症治疗功能评估通用版、良性前列腺增生影响指数及其他问题。既往前列腺手术史和神经泌尿疾病为排除标准，但使用泌尿药物不在此列。
LUTS和QOL与年龄显著相关，年龄较大的患者症状更多，QOL更差。此外，结果显示LUTS与QOL之间呈负相关。根据国际前列腺症状评分划分严重程度组，结果显示重度组患者的QOL显著差于中度组。在控制年龄的情况下，国际前列腺症状评分项目可解释FACT-G中32%的方差。夜尿症合并膀胱排空不全是QOL最强的预测因素。
LUTS对患者的总体健康状况有相当大的影响。结合年龄因素，它们可解释QOL中高达30%的方差。夜尿症和排空不全是最麻烦的症状。
