Institut national de la santé et de la recherche médicale, Unité Mixte de Recherche U1236, Université Rennes 1, Etablissement Français du Sang Bretagne, Rennes, France.
Centre Hospitalier Universitaire de Rennes, Pôle Biologie, Rennes, France.
Methods Mol Biol. 2021;2236:57-66. doi: 10.1007/978-1-0716-1060-2_6.
Myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs) are heterogeneous cells that share myeloid markers and are not easily distinguishable in human tumors due to their lack of specific markers. These cells are a major player in the tumor microenvironment and are involved in the prognosis and physiopathology of various tumors. Here is presented a scheme to decipher these cells by mass cytometry.
髓系来源的抑制细胞（MDSCs）和肿瘤相关巨噬细胞（TAMs）是异质性细胞，由于缺乏特异性标志物，它们具有髓系标志物，在人类肿瘤中不易区分。这些细胞是肿瘤微环境中的主要参与者，参与各种肿瘤的预后和病理生理学。这里提出了一种通过质谱流式细胞术破译这些细胞的方案。
