Department of Dermatology, Hospital for Skin Diseases (Institute of Dermatology), Chinese Academy of Medical Sciences & Peking Union Medical Collage, Nanjing, Jiangsu 210042, China.
Chin Med J (Engl). 2020 Nov 20;133(24):2976-2986. doi: 10.1097/CM9.0000000000001242.
Psoriasis is considered a systemic disease associated with metabolic abnormalities, and it is important to understand the mechanisms by which metabolism affects pathophysiological processes both holistically and systematically. Metabolites are closely related to disease phenotypes, especially in systemic diseases under multifactorial modulation. The emergence of metabolomics has provided information regarding metabolite changes in lesions and circulation and deepened our understanding of the association between metabolic reprogramming and psoriasis. Metabolomics has great potential for the development of effective biomarkers for clinical diagnosis, therapeutic monitoring, prediction of the efficacy of psoriasis management, and further discovery of new metabolism-based therapeutic targets.
银屑病被认为是一种与代谢异常相关的系统性疾病，了解代谢如何整体和系统地影响病理生理过程的机制非常重要。代谢物与疾病表型密切相关，尤其是在多因素调节的系统性疾病中。代谢组学的出现提供了有关病变和循环中代谢物变化的信息，加深了我们对代谢重编程与银屑病之间关联的理解。代谢组学为开发用于临床诊断、治疗监测、预测银屑病管理疗效的有效生物标志物以及进一步发现基于新代谢的治疗靶点具有巨大潜力。
