Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD 20993, USA.
Celigenex, Inc., Fort Lauderdale, FL 33308, USA.
Int J Mol Sci. 2020 Nov 23;21(22):8853. doi: 10.3390/ijms21228853.
Recent years have seen a marked rise in implantation into the body of a great variety of devices: hip, knee, and shoulder replacements, pacemakers, meshes, glucose sensors, and many others. Cochlear and retinal implants are being developed to restore hearing and sight. After surgery to implant a device, adjacent cells interact with the implant and release molecular signals that result in attraction, infiltration of the tissue, and attachment to the implant of various cell types including monocytes, macrophages, and platelets. These cells release additional signaling molecules (chemokines and cytokines) that recruit tissue repair cells to the device site. Some implants fail and require additional revision surgery that is traumatic for the patient and expensive for the payer. This review examines the literature for evidence to support the possibility that fibronectins and BMPs could be coated on the implants as part of the manufacturing process so that the proteins could be released into the tissue surrounding the implant and improve the rate of successful implantation.
近年来，人们将各种各样的设备植入体内的情况明显增多：髋关节、膝关节和肩关节置换、心脏起搏器、网片、葡萄糖传感器等等。人们正在开发耳蜗和视网膜植入物以恢复听力和视力。在植入设备的手术后，相邻的细胞与植入物相互作用并释放分子信号，导致组织的吸引、渗透以及各种细胞类型（包括单核细胞、巨噬细胞和血小板）附着在植入物上。这些细胞释放额外的信号分子（趋化因子和细胞因子），将组织修复细胞募集到设备部位。一些植入物会失效，需要进行额外的修复手术，这对患者和支付方来说都是创伤性的。这篇综述检查了文献中的证据，以支持在制造过程中在植入物上涂覆纤连蛋白和 BMP 的可能性，以便将蛋白质释放到植入物周围的组织中，并提高植入的成功率。
