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用于化妆品应用的抗皮肤衰老成分的天然来源。

: A Natural Source of Anti-Skin-Aging Ingredients for Cosmetic Applications.

作者信息

Yeerong Kankanit, Chantawannakul Panuwan, Anuchapreeda Songyot, Rades Thomas, Müllertz Anette, Chaiyana Wantida

机构信息

Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.

Bee Protection Laboratory, Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand.

出版信息

Pharmaceuticals (Basel). 2024 Mar 7;17(3):346. doi: 10.3390/ph17030346.

DOI:10.3390/ph17030346
PMID:38543133
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10974149/
Abstract

is an edible insect, rich in nutritional value and considered a sustainable protein source. This study aimed to investigate the potential application of extracts for anti-skin-aging purposes. The extracts were prepared by maceration at ambient temperature with 95% ethanol or hexane and maceration in gentle heat (45 °C) with 95% / ethanol or DI water. The extracts were examined for total protein, phenolic, and flavonoid contents. Protein molecular weight distribution was analyzed. The safety of the extracts was investigated in terms of irritation and cytotoxicity. Biological activities relevant to the inhibition of skin aging were evaluated, including increasing transforming growth factor-beta 1 (TGF-β1) expression and inhibitory activities on collagenase and hyaluronidase. The aqueous extract from maceration in gentle heat had the highest total protein content (63 ± 1% /), total phenolic content (0.48 ± 0.03 mg GAE/g extract), TGF-β1 stimulating activities (33 ± 2 pg/mL), and collagenase inhibition (with a half maximal inhibitory concentration of 26 ± 1 µg/mL) among various extracts investigated. It caused no irritation to the hen's egg chorioallantoic membrane and showed no cytotoxicity to human dermal fibroblasts and peripheral blood mononuclear cells. Therefore, aqueous extract is proposed as an innovative natural anti-skin-aging ingredient.

摘要

是一种可食用昆虫，营养价值高，被认为是一种可持续的蛋白质来源。本研究旨在探讨提取物在抗皮肤衰老方面的潜在应用。提取物通过在室温下用95%乙醇或己烷浸渍以及在温和加热（45°C）下用95%乙醇或去离子水浸渍来制备。对提取物的总蛋白、酚类和黄酮类含量进行了检测。分析了蛋白质分子量分布。从刺激性和细胞毒性方面研究了提取物的安全性。评估了与抑制皮肤衰老相关的生物活性，包括增加转化生长因子-β1（TGF-β1）表达以及对胶原酶和透明质酸酶的抑制活性。在研究的各种提取物中，温和加热浸渍得到的水提取物总蛋白含量最高（63±1%/）、总酚含量最高（0.48±0.03mg GAE/g提取物）、TGF-β1刺激活性最高（33±2pg/mL）以及胶原酶抑制活性最高（半数最大抑制浓度为26±1μg/mL）。它对鸡胚绒毛尿囊膜无刺激性，对人皮肤成纤维细胞和外周血单核细胞无细胞毒性。因此，水提取物被提议作为一种创新的天然抗皮肤衰老成分。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3e0/10974149/a180abdb5699/pharmaceuticals-17-00346-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3e0/10974149/dc288d7cd9db/pharmaceuticals-17-00346-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3e0/10974149/38265b075ac9/pharmaceuticals-17-00346-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3e0/10974149/1f5182f7ba4c/pharmaceuticals-17-00346-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3e0/10974149/a938aafc7a7b/pharmaceuticals-17-00346-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3e0/10974149/a32b25a010c0/pharmaceuticals-17-00346-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3e0/10974149/1fc7cfd2b714/pharmaceuticals-17-00346-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3e0/10974149/4b8bc7690ce6/pharmaceuticals-17-00346-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3e0/10974149/a180abdb5699/pharmaceuticals-17-00346-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3e0/10974149/dc288d7cd9db/pharmaceuticals-17-00346-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3e0/10974149/38265b075ac9/pharmaceuticals-17-00346-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3e0/10974149/1f5182f7ba4c/pharmaceuticals-17-00346-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3e0/10974149/a938aafc7a7b/pharmaceuticals-17-00346-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3e0/10974149/a32b25a010c0/pharmaceuticals-17-00346-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3e0/10974149/1fc7cfd2b714/pharmaceuticals-17-00346-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3e0/10974149/4b8bc7690ce6/pharmaceuticals-17-00346-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3e0/10974149/a180abdb5699/pharmaceuticals-17-00346-g008.jpg

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