OrganoVIR Labs, Department of Medical Microbiology, Amsterdam UMC, Location Academic Medical Center, University of Amsterdam, 1100 AZ Amsterdam, The Netherlands.
Department of Pediatric Infectious Diseases, Emma Children's Hospital, Amsterdam UMC, Location Academic Medical Center, University of Amsterdam, 1100 AZ Amsterdam, The Netherlands.
Viruses. 2020 Nov 23;12(11):1341. doi: 10.3390/v12111341.
Animal models and cell lines are invaluable for virology research and host-pathogen interaction studies. However, it is increasingly evident that these models are not sufficient to fully understand human viral diseases. With the advent of three-dimensional organotypic cultures, it is now possible to study viral infections in the human context. This perspective explores the potential of these organotypic cultures, also known as organoids, for virology research, antiviral testing, and shaping the virology landscape.
动物模型和细胞系在病毒学研究和宿主-病原体相互作用研究中具有不可估量的价值。然而，越来越明显的是，这些模型不足以完全理解人类病毒疾病。随着三维器官型培养物的出现，现在可以在人类环境中研究病毒感染。本文探讨了这些器官型培养物（也称为类器官）在病毒学研究、抗病毒测试和塑造病毒学领域的潜力。
