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2013-2017 年针对精神健康不佳人群的国民保健服务健康检查:一项观察性研究。

NHS Health Checks for people with mental ill-health 2013-2017: an observational study.

机构信息

Nuffield Department of Primary Care Health Science, University of Oxford, Oxford, UK.

出版信息

Epidemiol Psychiatr Sci. 2020 Nov 26;29:e188. doi: 10.1017/S2045796020001006.

Abstract

AIMS

People living with serious mental ill-health experience adverse cardiovascular outcomes causing some of the greatest health inequality gaps in England, UK. We describe uptake of the NHS Health Check programme in people with mental ill-health, and rates of new diagnoses and management of cardiovascular risk factors in those who attend NHS Health Checks in comparison to those people without mental ill-health.

METHODS

We used a large nationally representative database of people registered with general practitioners in England (QResearch). Between 2013 and 2017, we analysed attendance at NHS Health Checks and outcomes in the succeeding 12 months, in people with serious mental illness (SMI) including psychoses and in people prescribed long-term antidepressant medications (LTAD), with comparison to attendees who did not have these conditions. Hazard ratios (HR) were used to describe the association between outcomes and SMI and LTAD adjusting for sociodemographic variables.

RESULTS

In those eligible for the NHS Health Check programme, we found a higher percentage of people with SMI attended an NHS Health Check (65 490, 19.8%) than those without SMI (524 728, 16.6%); adjusted HR 1.05 [95% confidence interval 1.02-1.08]. We also observed a higher percentage of attendance in people on LTAD (46 437, 20.1%) compared to people who were not prescribed LTAD (543 781, 16.7%); adjusted HR 1.10 (1.08-1.13). People with SMI were more likely to be identified with chronic kidney disease (CKD, HR 1.23, 1.12-1.34) and type 2 diabetes (HR 1.14, 1.03-1.25) within the 12 months following their NHS Health Check compared with those without SMI. People on LTAD were more likely to be identified with CKD (HR 1.55, 1.42-1.70) and type 2 diabetes (HR 1.45, 1.31-1.60) and also hypertension, cardiovascular disease, non-diabetic hyperglycaemia, familial hypercholesterolemia and dementia within the 12 months following their NHS Health Check. Statins were more likely to be prescribed to NHS Health Check attendees with SMI and those on LTAD than those without these conditions; HR 1.31 (1.25-1.38) and 1.91 (1.82-2.01), respectively. Antihypertensives were more likely to be prescribed to those on LTAD; HR 1.21 (1.14-1.29).

CONCLUSIONS

We found evidence that people with SMI or on LTAD treatment were 5-10% more likely to access NHS Health Checks than people without these conditions. People with SMI or on LTAD treatment who attended NHS Health Checks had higher rates of diagnosis of CKD, type 2 diabetes and some other relevant co-morbidities and increased treatment with statins and also anti-hypertensive medication in people on LTAD. This is likely to contribute to equitable reduction in adverse cardiovascular events for people with mental ill-health.

摘要

目的

在英国,患有严重精神健康问题的人会出现不良心血管结局,导致最大的健康不平等差距之一。我们描述了在有精神健康问题的人群中参加国民保健制度健康检查计划的情况,以及在参加国民保健制度健康检查的人群中,新诊断出心血管风险因素和管理这些因素的比率,与没有精神健康问题的人群相比。

方法

我们使用了一个英国全国代表性的注册全科医生数据库(QResearch)。在 2013 年至 2017 年期间,我们分析了严重精神疾病(包括精神病)患者和长期服用抗抑郁药(LTAD)患者参加国民保健制度健康检查及其随后 12 个月的结果,并与没有这些疾病的患者进行了比较。使用风险比(HR)来描述与严重精神疾病和 LTAD 相关的结局的关联,同时调整了社会人口统计学变量。

结果

在有资格参加国民保健制度健康检查计划的人群中,我们发现患有严重精神疾病的人参加国民保健制度健康检查的比例(65490 人,19.8%)高于没有严重精神疾病的人(524728 人,16.6%);调整后的 HR 为 1.05[95%置信区间 1.02-1.08]。我们还观察到,服用 LTAD 的人参加国民保健制度健康检查的比例(46437 人,20.1%)高于没有服用 LTAD 的人(543781 人,16.7%);调整后的 HR 为 1.10(1.08-1.13)。与没有严重精神疾病的人相比,患有严重精神疾病的人在接受国民保健制度健康检查后的 12 个月内,更有可能被诊断出慢性肾脏病(CKD,HR 1.23,1.12-1.34)和 2 型糖尿病(HR 1.14,1.03-1.25)。服用 LTAD 的人更有可能在接受国民保健制度健康检查后的 12 个月内被诊断出 CKD(HR 1.55,1.42-1.70)和 2 型糖尿病(HR 1.45,1.31-1.60),以及高血压、心血管疾病、非糖尿病性高血糖、家族性高胆固醇血症和痴呆症。他汀类药物更有可能被开给有严重精神疾病和 LTAD 治疗的国民保健制度健康检查参与者,而不是没有这些疾病的参与者;HR 分别为 1.31(1.25-1.38)和 1.91(1.82-2.01)。抗高血压药物更有可能被开给服用 LTAD 的人;HR 为 1.21(1.14-1.29)。

结论

我们发现有证据表明,患有严重精神疾病或正在服用 LTAD 治疗的人比没有这些疾病的人更有可能接受国民保健制度健康检查。参加国民保健制度健康检查的患有严重精神疾病或正在服用 LTAD 治疗的人,CKD、2 型糖尿病和其他一些相关合并症的诊断率较高,并且在服用 LTAD 的人中,他汀类药物和抗高血压药物的治疗率也有所增加。这可能有助于减少精神健康不良者的不良心血管事件。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b33/7737190/e8446909e8ee/S2045796020001006_fig1.jpg

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