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可卡因和甲基苯丙胺:药理学和牙科影响。

Cocaine and methamphetamine: Pharmacology and dental implications.

机构信息

Dental student (4th year), Faculty of Dentistry, University of Toronto, Toronto, ON, Canada.

Assistant professor, Department of Clinical Sciences (Pharmacology and Preventive Dentistry), Faculty of Dentistry, University of Toronto, Toronto, ON, Canada.

出版信息

Can J Dent Hyg. 2020 Jun 1;54(2):75-82.

Abstract

BACKGROUND

Epidemiological studies have shown that illicit drug use is a persistent and growing problem in our society. Methamphetamine and cocaine are at the top of the list of stimulants commonly abused. There is a need for a disease-targeted approach to the dental management of clients who use these drugs.

METHODS

A review of the literature was conducted to identify the most up-to-date information for the diagnosis and treatment of dental clients who abuse methamphetamine and cocaine. Databases in the University of Toronto library system were searched for peer-reviewed articles, written in English, and containing data relevant to clinical decision making. Textbooks were chosen from a list of reference materials provided by the National Dental Examination Board. All cited articles were published within the past 5 years.

RESULTS AND DISCUSSION

There is robust literature on the treatment of individual signs and symptoms associated with methamphetamine and cocaine use. However, there is a dearth of information on the comprehensive, client-centred oral health care that these individuals require.

CONCLUSION

This article reviews the best practices to guide the clinician from the initial oral diagnosis appointment to the maintenance of care, including the pharmacological actions of these drugs of abuse, the specific challenges faced in providing care for this client population, and scientifically based treatment considerations to maximize prognosis.

摘要

背景

流行病学研究表明,非法药物使用是我们社会中一个持续存在且不断增长的问题。安非他命和可卡因是最常被滥用的兴奋剂之首。对于使用这些药物的客户,需要采取针对疾病的方法来进行牙科管理。

方法

对文献进行了回顾,以确定有关滥用安非他命和可卡因的牙科客户的诊断和治疗的最新信息。在多伦多大学图书馆系统的数据库中搜索了同行评议的文章,这些文章以英文撰写,并包含与临床决策相关的数据。教科书选自国家牙科考试委员会提供的参考资料清单。所有引用的文章均在过去 5 年内发表。

结果和讨论

有大量关于与安非他命和可卡因使用相关的个体症状的治疗的文献。但是,对于这些人需要的全面、以客户为中心的口腔保健信息却很少。

结论

本文综述了指导临床医生从初始口腔诊断预约到维持治疗的最佳实践,包括这些滥用药物的药理学作用、为该客户群体提供护理所面临的具体挑战以及基于科学的治疗考虑因素,以最大限度地提高预后。

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本文引用的文献

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Oral manifestations of illicit drug use.非法药物使用的口腔表现。
Aust Dent J. 2019 Sep;64(3):213-222. doi: 10.1111/adj.12709. Epub 2019 Jul 30.
8
Mechanisms underlying methamphetamine-related dental disease.导致冰毒相关牙科疾病的机制。
J Am Dent Assoc. 2017 Jun;148(6):377-386. doi: 10.1016/j.adaj.2017.02.054. Epub 2017 Apr 27.
9
Methamphetamine: Effects on the brain, gut and immune system.甲基苯丙胺:对大脑、肠道和免疫系统的影响。
Pharmacol Res. 2017 Jun;120:60-67. doi: 10.1016/j.phrs.2017.03.009. Epub 2017 Mar 14.

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