用于药物递送的多响应性丝素蛋白基纳米颗粒
Multi-Responsive Silk Fibroin-Based Nanoparticles for Drug Delivery.
作者信息
Ma Ya, Canup Brandon S B, Tong Xiaoling, Dai Fangyin, Xiao Bo
机构信息
State Key Laboratory of Silkworm Genome Biology, Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing, China.
Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing, School of Materials and Energy, Southwest University, Chongqing, China.
出版信息
Front Chem. 2020 Nov 3;8:585077. doi: 10.3389/fchem.2020.585077. eCollection 2020.
Silk fibroin has the merits of biocompatibility, biodegradability, ease of processing, and feasibility of modification, which present it as a promising drug delivery material. This review focuses on the structures of silk fibroin, the controlled transformation of secondary structures, and the formation mechanism of silk fibroin-based nanoparticles (SFNPs). We also discuss the intrinsic multi-responsive, surface functionalization, and transgenic modification of SFNPs for drug delivery.
丝素蛋白具有生物相容性、生物可降解性、易于加工以及可修饰性等优点，使其成为一种很有前景的药物递送材料。本综述聚焦于丝素蛋白的结构、二级结构的可控转变以及丝素蛋白基纳米颗粒（SFNPs）的形成机制。我们还讨论了用于药物递送的SFNPs的固有多重响应性、表面功能化及转基因修饰。
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