基于丝素蛋白的纳米治疗药物：在结肠疾病治疗中的应用。
Silk fibroin-based nanotherapeutics: application in the treatment of colonic diseases.
机构信息
State Key Laboratory of Silkworm Genome Biology, School of Materials & Energy, Southwest University, Beibei, Chongqing 400715, PR China.
Chongqing Key Laboratory of Soft-Matter Material Chemistry & Function Manufacturing, School of Materials & Energy, Southwest University, Beibei, Chongqing 400715, PR China.
出版信息
Nanomedicine (Lond). 2019 Sep;14(17):2373-2378. doi: 10.2217/nnm-2019-0058. Epub 2019 Jul 10.
Abstract
The incidence of colonic diseases (e.g., inflammatory bowel diseases and colon cancer) is rapidly rising. Nanotherapeutic has been considered as a promising strategy in the treatment of colonic diseases. Silk fibroin (SF) has been widely used as a drug-carrier matrix. Interestingly, SF-based nanoparticles (SFNPs) have intrinsic anti-inflammatory activity, wound healing capacity and lysosomal environment-responsive drug-release property. With further investigations, the sequences of SF molecules could be precisely modified through chemical reactions or transgenic techniques to greatly improve the properties of SFNPs. Here, we review recent advances in the application of SFNPs toward the treatment of colonic diseases. We also discuss future developments that might improve the anti-inflammatory and anti-colon cancer activities of SF-based nanotherapeutics.
摘要
结肠疾病（如炎症性肠病和结肠癌）的发病率正在迅速上升。纳米治疗已被认为是治疗结肠疾病的一种有前途的策略。丝素蛋白（SF）已被广泛用作药物载体基质。有趣的是，基于 SF 的纳米颗粒（SFNPs）具有内在的抗炎活性、伤口愈合能力和溶酶体环境响应性药物释放特性。通过进一步的研究，可以通过化学反应或转基因技术精确修饰 SF 分子的序列，从而极大地改善 SFNPs 的性能。在这里，我们综述了 SFNPs 在治疗结肠疾病方面的最新应用进展。我们还讨论了可能提高基于 SF 的纳米治疗剂抗炎和抗结肠癌活性的未来发展。
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