Wang Xiaolei, Li Shi-Ming, Liu Luoru, Li Siyuan, Li Lei, Kang Mengtian, Wei Shifei, Wang Ningli
Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology & Visual Science Key Lab, Beijing Institute of Ophthalmology, Capital Medical University, Beijing, China.
Transl Pediatr. 2021 Aug;10(8):2052-2062. doi: 10.21037/tp-21-323.
This study used spectral-domain optical coherence tomography (SD-OCT) imaging to describe the distribution of macular ganglion cell complex (GCC) thickness and its association with ocular and systemic parameters in 7-year-old children in China.
The study involved a school-based, cross-sectional analysis of the Anyang Childhood Eye Study (ACES) and included 2,505 first-grade students from urban areas in Anyang, Henan Province, Central China. All participants underwent systemic and ocular examinations. Both GCC and retinal nerve fiber layer (RNFL) thickness were measured using the iVue-100 OCT (Optovue, Fremont, CA, USA). Intraocular pressure (IOP) was recorded with noncontact tonometer (Huvitz, HNT-7000). Axial length (AL) was measured using optical biometry (Lenstar LS 900, Haag-Streit Diagnostics, Koniz, Switzerland).
The mean GCC thickness was 95.31±7.67 µm. GCC thickness had negative associations with AL (r=-0.124, P<0.001), cup-to-disc (C-D) area ratio (r=-0.068, P=0.0033), horizontal C-D (H C-D) ratio (r=-0.048, P=0.0384), and vertical C-D (V C-D) ratio (r=-0.074, P=0.0013). Positive correlations were found with spherical equivalent (SE) (r=0.080, P=0.0001), RNFL thickness (r=0.363, P<0.001), height (r=0.059, P=0.0036), fovea parameters, disc area (r=0.078, P=0.0007), rim area (r=0.115, P<0.001), rim volume (r=0.119, P<0.001), and optic nerve head volume (r=0.097, P<0.001). GCC thickness had no significant association with IOP, age, sex, or weight, waist, or head circumference.
This study provides normative GCC data for 7-year-old healthy children in China. The findings support an association between GCC and AL, SE, RNFL, height, and C-D ratio in children.
本研究采用频域光学相干断层扫描（SD-OCT）成像技术，描述中国7岁儿童黄斑神经节细胞复合体（GCC）厚度的分布情况及其与眼部和全身参数的关联。
本研究纳入了安阳儿童眼病研究（ACES）的一项基于学校的横断面分析，研究对象为来自中国中部河南省安阳市市区的2505名一年级学生。所有参与者均接受了全身和眼部检查。使用iVue-100 OCT（美国加利福尼亚州弗里蒙特市Optovue公司）测量GCC和视网膜神经纤维层（RNFL）的厚度。使用非接触眼压计（韩国Huvis公司，HNT-7000）记录眼压（IOP）。使用光学生物测量仪（瑞士科尼市Haag-Streit诊断公司的Lenstar LS 900）测量眼轴长度（AL）。
GCC的平均厚度为95.31±7.67µm。GCC厚度与AL（r=-0.124，P<0.001）、杯盘（C-D）面积比（r=-0.068，P=0.0033）、水平杯盘（H C-D）比（r=-0.048，P=0.0384）和垂直杯盘（V C-D）比（r=-0.074，P=0.0013）呈负相关。与等效球镜度（SE）（r=0.080，P=0.0001）、RNFL厚度（r=0.363，P<0.001）、身高（r=0.059，P=0.0036）、黄斑中心凹参数、视盘面积（r=0.078，P=0.0007）、视盘边缘面积（r=0.115，P<0.001）、视盘边缘体积（r=0.119，P<0.001）和视神经乳头体积（r=0.097，P<0.001）呈正相关。GCC厚度与IOP、年龄、性别或体重、腰围或头围无显著关联。
本研究为中国7岁健康儿童提供了GCC的规范性数据。研究结果支持儿童GCC与AL、SE、RNFL、身高和C-D比之间存在关联。
