Unidad Alergia, Hospital de Fuenlabrada, Madrid, Spain.
J Investig Allergol Clin Immunol. 2011;21(4):278-82.
Lipid transfer proteins (LTPs) and profilins are the most important panallergens in the management of patients who are allergic to pollen and plant food in our area. LTPs are highly stable proteins that can induce systemic symptoms after ingestion. Profilins are labile proteins that are present in pollens and vegetables. Considered markers of several types of pollen sensitization, they are responsible for cross-reactivity between pollens and vegetables. The objective of this study was to assess the frequency of sensitization to LTP and profilin using skin prick tests (SPTs) in patients referred to our allergy unit for any complaint (not only pollen and plant food allergy).
The study sample comprised 430 consecutive patients who were evaluated using their medical history and SPTs with pollen, date palm profilin, and peach extract enriched in Pru p 3 (30 g/mL) as an LTP marker.
We found that 52 (12.1%) patients were sensitized to profilin and 53 (12.3%) to LTP. Pollen allergy was diagnosed in 53% and plant food allergy in 11%. In the LTP-sensitized group and the profilin-sensitized group, 37.7% and 34.6% of the patients had plant food allergy, respectively. Thirty-three patients (62.3%) were sensitized to LTP but had no symptoms after eating vegetables.
To the best of our knowledge, this is the first study to analyze the real rate of sensitization to profilin and LTP in a population sensitized to allergens other than pollens and plant foods. Twelve percent of patients were sensitized to both profilin and LTP. A large proportion of LTP-sensitized patients had no symptoms at the time of the study.
脂质转移蛋白（LTPs）和丝状蛋白是我们地区花粉和植物性食物过敏患者管理中最重要的泛过敏原。LTPs 是高度稳定的蛋白质，摄入后可引起全身症状。丝状蛋白是不稳定的蛋白质，存在于花粉和蔬菜中。作为几种花粉致敏的标志物，它们是花粉和蔬菜之间交叉反应的原因。本研究旨在评估通过皮肤点刺试验（SPTs）在因任何症状（不仅是花粉和植物性食物过敏）而就诊于我们过敏科的患者中检测到 LTP 和丝状蛋白致敏的频率。
研究样本包括 430 例连续患者，通过病史和 SPTs 进行评估，SPTs 使用花粉、椰枣丝状蛋白和富含 Pru p 3（30μg/ml）的桃提取物作为 LTP 标志物。
我们发现 52 例（12.1%）患者对丝状蛋白敏感，53 例（12.3%）对 LTP 敏感。诊断花粉过敏 53%，植物性食物过敏 11%。在 LTP 致敏组和丝状蛋白致敏组中，分别有 37.7%和 34.6%的患者有植物性食物过敏。33 例（62.3%）患者对 LTP 致敏，但食用蔬菜后无任何症状。
据我们所知，这是第一项分析除花粉和植物性食物之外的过敏原致敏人群中对丝状蛋白和 LTP 实际致敏率的研究。12%的患者对丝状蛋白和 LTP 均致敏。在研究时，大量 LTP 致敏患者无症状。
