临床实践中用于肥胖治疗的原发性肥胖症内镜手术（POSE-2 术式）。
Primary obesity surgery endoluminal (POSE-2) procedure for treatment of obesity in clinical practice.
机构信息
Bariatric Endoscopy Unit, HM Sanchinarro Hospital, Madrid, Spain.
Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore.
出版信息
Endoscopy. 2021 Nov;53(11):1169-1173. doi: 10.1055/a-1324-8498. Epub 2021 Jan 21.
BACKGROUND
The POSE-2 procedure shortens and narrows the stomach using multiple full-thickness plications in the gastric body. We studied the efficacy and safety of POSE-2 for obesity at 1 year in a real-world setting.
METHODS
We reviewed the records of 75 patients who underwent POSE-2 at our unit. The primary outcome was percentage total body weight loss (%TBWL) at 1 year. Secondary outcomes were safety and durability. We used linear mixed model analysis.
RESULTS
46 patients completed 1 year. Mean age and body mass index (BMI) were 49.3 years (standard deviation [SD] 10.2) and 38.2 kg/m (SD 6.6), respectively. Technical success rate was 98.7 % (n = 74). Mean TBWL, %TBWL, and BMI decline at 1 year were 20 kg (SD 12.7), 17.8 % (SD 9.5), 7 kg/m (SD 4.3). Adverse events occurred in four patients. The median length of stay was 1 day. Endoscopy at 1 year in 15 patients showed intact sutures and a reduction in gastric length compared with baseline (26.9 cm [SD 5.3] vs. 35.7 cm [SD 3.5]; < 0.001).
CONCLUSION
POSE-2 induced significant weight loss at 1 year. It appears to be safe, durable, and required only a short hospital stay.
背景
POSE-2 手术通过在胃体进行多次全层折叠来缩短和缩窄胃。我们在真实环境中研究了 POSE-2 治疗肥胖症的 1 年疗效和安全性。
方法
我们回顾了在我们科室接受 POSE-2 手术的 75 名患者的记录。主要结果是 1 年后的总体重减轻百分比（%TBWL）。次要结果是安全性和持久性。我们使用线性混合模型分析。
结果
46 名患者完成了 1 年随访。平均年龄和体重指数（BMI）分别为 49.3 岁（标准差 [SD] 10.2）和 38.2kg/m（SD 6.6）。技术成功率为 98.7%（n=74）。1 年后的平均 TBWL、%TBWL 和 BMI 下降分别为 20kg（SD 12.7）、17.8%（SD 9.5）和 7kg/m（SD 4.3）。四名患者发生了不良事件。中位住院时间为 1 天。15 名患者在 1 年时进行内镜检查显示缝线完整，与基线相比胃长度减少（26.9cm[SD 5.3]比 35.7cm[SD 3.5]；<0.001）。
结论
POSE-2 在 1 年内诱导了显著的体重减轻。它似乎是安全的、持久的，并且只需要短暂的住院时间。
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