Zhou Li, Li Jun-Yi, He Ping-Ping, Yu Xiao-Hua, Tang Chao-Ke
Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Medical Research Experiment Center, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.
School of Nursing, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, Hunan 421001, China.
Clin Chim Acta. 2021 Jan;512:84-91. doi: 10.1016/j.cca.2020.11.010. Epub 2020 Nov 27.
Resistin, a cysteine-rich secretory protein, has a pleiotropic role in humans. Resistin usually presents as trimer or hexamer in plasma, and targets specific receptors Toll Like Receptor 4 (TLR4) or Adenylyl Cyclase-Associated Protein 1 (CAP1). Upon binding to TLR4 and CAP1, resistin can trigger various intracellular signal transduction pathways to induce vascular inflammation, lipid accumulation, and plaque vulnerability. These pro-atherosclerotic effects of resistin appear in various cell types, including endothelial cells, vessel smooth muscle cells and macrophages, which cause diverse damages to cardiovascular system from dyslipidemia, atherosclerosis rupture and ventricular remodeling. In this review, we gather recent evidence about the pro- atherosclerotic effects of resistin and highlight it as a candidate therapeutic or diagnostic target for cardiovascular disease.
抵抗素是一种富含半胱氨酸的分泌蛋白，在人体内具有多效性作用。抵抗素在血浆中通常以三聚体或六聚体形式存在，并作用于特定受体——Toll样受体4（TLR4）或腺苷酸环化酶相关蛋白1（CAP1）。与TLR4和CAP1结合后，抵抗素可触发各种细胞内信号转导通路，从而诱导血管炎症、脂质蓄积和斑块易损性。抵抗素的这些促动脉粥样硬化作用出现在包括内皮细胞、血管平滑肌细胞和巨噬细胞在内的多种细胞类型中，这些作用会从血脂异常、动脉粥样硬化破裂和心室重塑等方面对心血管系统造成多种损害。在本综述中，我们收集了有关抵抗素促动脉粥样硬化作用的最新证据，并强调其作为心血管疾病候选治疗或诊断靶点的地位。
