Department of Cardiology, Adiyaman Education and Research Hospital, Adiyaman, Turkey.
Department of cardiology, Kahta State Hospital, Kâhta, Turkey.
Curr Cardiol Rev. 2022;18(1):e290721195114. doi: 10.2174/1573403X17666210729101120.
Serum resistin, mainly secreted by the bone marrow, monocytes, and macrophages, contributes to many processes, including endothelial dysfunction, Vascular Smooth Muscle Cell (VSMC) proliferation, and atherothrombosis demonstrating effects on the development of hypertension and Coronary Artery Disease (CAD). Previously published clinical studies have shown that plasma resistin levels are significantly associated with cardiovascular disease risk factors and adverse clinical outcomes associated with the condition. Resistin is associated with vascular smooth muscle cell dysfunction in vitro, most plausibly due to its relationship with oxidative stress in advanced atherosclerosis whereas in vivo studies have shown resistin to be associated with intimal hyperplasia. We aimed to summarize the role of resistin on cardiovascular disease (CVD), as we could not find any review focused on the role of resistin on CVD.
血清抵抗素主要由骨髓、单核细胞和巨噬细胞分泌，参与许多过程，包括内皮功能障碍、血管平滑肌细胞（VSMC）增殖和动脉粥样血栓形成，对高血压和冠状动脉疾病（CAD）的发展有影响。先前发表的临床研究表明，血浆抵抗素水平与心血管疾病危险因素显著相关，并与该疾病相关的不良临床结局相关。抵抗素与体外血管平滑肌细胞功能障碍有关，最可能是由于其与晚期动脉粥样硬化中的氧化应激有关，而体内研究表明抵抗素与内膜增生有关。我们旨在总结抵抗素在心血管疾病（CVD）中的作用，因为我们没有找到任何专门针对抵抗素在 CVD 中作用的综述。
