McMurry L M, Park B H, Burdett V, Levy S B
Department of Molecular Biology, Tufts University School of Medicine, Boston, Massachusetts 02111.
Antimicrob Agents Chemother. 1987 Oct;31(10):1648-50. doi: 10.1128/AAC.31.10.1648.
The class L (TetL) tetracycline resistance determinant from streptococci specified resistance and an energy-dependent decreased accumulation of tetracycline in both Streptococcus faecalis and Escherichia coli. Using E. coli, we showed that the reduced uptake resulted from active efflux. The streptococcal class M determinant, known to render the protein synthesis machinery of S. faecalis resistant to tetracycline inhibition, did not alter tetracycline transport in either host.
来自链球菌的L类（TetL）四环素抗性决定簇赋予了粪肠球菌和大肠杆菌对四环素的抗性以及能量依赖的四环素积累减少。利用大肠杆菌，我们发现摄取减少是由主动外排导致的。已知能使粪肠球菌的蛋白质合成机制对四环素抑制产生抗性的链球菌M类决定簇，在两种宿主中均未改变四环素的转运。
