Ghorbani Mahin, Rajandas Heera, Parimannan Sivachandran, Stephen Joseph Gerard Benedict, Tew Mei Mei, Ramly Siti Salwa, Muhamad Rasat Muhammad Arif, Lee Su Yin
Centre of Excellence for Omics-Driven Computational Biodiscovery (COMBio), Faculty of Applied Sciences, AIMST University.
Clinical Research Centre (CRC), Hospital Sultanah Bahiyah, Alor Setar.
Psychiatr Genet. 2021 Apr 1;31(2):39-49. doi: 10.1097/YPG.0000000000000270.
Schizophrenia is a chronic mental disorder with marked symptoms of hallucination, delusion, and impaired cognitive behaviors. Although multidimensional factors have been associated with the development of schizophrenia, the principal cause of the disorder remains debatable. Microbiome involvement in the etiology of schizophrenia has been widely researched due to the advancement in sequencing technologies. This review describes the contribution of the gut microbiome in the development of schizophrenia that is facilitated by the gut-brain axis. The gut microbiota is connected to the gut-brain axis via several pathways and mechanisms, that are discussed in this review. The role of the oral microbiota, probiotics and prebiotics in shaping the gut microbiota are also highlighted. Lastly, future perspectives for microbiome research in schizophrenia are addressed.
精神分裂症是一种慢性精神障碍，具有明显的幻觉、妄想和认知行为受损症状。尽管多方面因素与精神分裂症的发展有关，但该疾病的主要病因仍存在争议。由于测序技术的进步，微生物群在精神分裂症病因学中的作用已得到广泛研究。本综述描述了肠道微生物群在精神分裂症发展中的作用，这一过程由肠-脑轴介导。肠道微生物群通过多种途径和机制与肠-脑轴相连，本综述将对此进行讨论。同时还强调了口腔微生物群、益生菌和益生元在塑造肠道微生物群方面的作用。最后，阐述了精神分裂症微生物组研究的未来前景。
