Yao Junji, Kang Yi, Jia Huan, Zhang Zhihua, Wang Zhaoyan, Huang Qi, Shi Jun, Wu Hao
Department of Otolaryngology Head and Neck Surgery，Shanghai Ninth People's Hospital，School of Medicine，Shanghai Jiao Tong University，Shanghai，200011，China.
Ear Institute，Shanghai Jiao Tong University School of Medicine.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020 Dec;34(12):1088-1092. doi: 10.13201/j.issn.2096-7993.2020.12.008.
To study the anatomical distribution and tumor extent of juvenile laryngeal papilloma（JLP）, and to sum up the similarity and difference in distribution between initiatial and recurrent tumor. Data of 65 patients with JLP who were admitted to the Ear Institute, School of Medicine, Shanghai Jiao Tong University from January 2011 to December 2018 were retrospectively analyzed. The RRP tumor assessment method proposed by Derkay et al. was referred to, in which larynx was divided in to 11 anatomical sites. 2.9±1.3 Laryngeal anatomical sites were involved in patients with initial tumor, while that was 3.1±1.5 in patients with recurrent tumor. The most common sites were true vocal fords, anterior commissure and false vocal fords in both group; and the least ones were subglottis, posterior glottis and ary-epiglottic fold. However, subglottis（=0.038） and trachea（=0.007） were more likely to be involved in recurrent tumor, with statistical differences. There were differences in distribution of JLP between initial and recurrent tumor, which might be the result of suitable areas for HPV survival or micro-lesion of residual tumor.
研究儿童喉乳头状瘤（JLP）的解剖分布及肿瘤范围，总结初发肿瘤与复发肿瘤在分布上的异同。回顾性分析2011年1月至2018年12月上海交通大学医学院附属耳科研究所收治的65例JLP患者的数据。参考Derkay等人提出的RRP肿瘤评估方法，将喉部划分为11个解剖部位。初发肿瘤患者累及2.9±1.3个喉解剖部位，复发肿瘤患者为3.1±1.5个。两组中最常见的部位均为真声带、前联合和假声带；最少见的是声门下区、后声门和杓会厌襞。然而，复发肿瘤更易累及声门下区（P=0.038）和气管（P=0.007），差异有统计学意义。JLP初发肿瘤与复发肿瘤的分布存在差异，这可能是HPV生存适宜区域或残留肿瘤微病变的结果。
