Department of Entomology, Plant Pathology and Nematology, University of Idaho, Moscow, ID 83844, USA.
Department of Biological Sciences, University of Idaho, Moscow, ID 83844, USA.
Genes (Basel). 2020 Nov 24;11(12):1393. doi: 10.3390/genes11121393.
The ancient stress signaling molecule abscisic acid (ABA) is ubiquitous in animals and plants but is perhaps most well-known from its early discovery as a plant hormone. ABA can be released into water by plants and is found in nectar, but is also present in mammalian blood, three key contexts for mosquito biology. We previously established that addition of ABA to larval rearing water altered immature development and life history traits of females derived from treated larvae, while addition of ABA to an infected bloodmeal increased resistance of adult female to human malaria parasite infection. Here we sought to determine whether larval treatment with ABA could similarly impact resistance to parasite infection in females derived from treated larvae and, if so, whether resistance could be extended to another parasite species. We examined nutrient levels and gene expression to demonstrate that ABA can transstadially alter resistance to a rodent malaria parasite with hallmarks of previously observed mechanisms of resistance following provision of ABA in blood to .
古老的应激信号分子脱落酸（ABA）在动植物中无处不在，但它最早作为一种植物激素被发现，因此最为人所熟知。ABA 可以由植物释放到水中，存在于花蜜中，但也存在于哺乳动物的血液中，这是蚊子生物学的三个关键环境。我们之前的研究表明，将 ABA 添加到幼虫饲养水中会改变来自处理过的幼虫的雌性个体的不成熟发育和生活史特征，而将 ABA 添加到感染的血餐中会增加成年雌性对人类疟疾寄生虫感染的抵抗力。在这里，我们试图确定幼虫期用 ABA 处理是否也可以类似地影响来自处理过的幼虫的雌性个体对寄生虫感染的抵抗力，如果可以，这种抵抗力是否可以扩展到另一种寄生虫物种。我们检查了营养水平和基因表达，以证明 ABA 可以在提供给蚊子的血液中发挥 ABA 作用的情况下，通过转代方式改变对一种啮齿动物疟疾寄生虫的抵抗力，具有先前观察到的抵抗机制的特征。
