Luckhart Shirley, Riehle Michael A
Department of Entomology, Plant Pathology and Nematology, University of Idaho, Moscow, ID, United States.
Department of Biological Sciences, University of Idaho, Moscow, ID, United States.
Front Cell Infect Microbiol. 2020 Dec 11;10:593159. doi: 10.3389/fcimb.2020.593159. eCollection 2020.
Across diverse organisms, various physiologies are profoundly regulated by mitochondrial function, which is defined by mitochondrial fusion, biogenesis, oxidative phosphorylation (OXPHOS), and mitophagy. Based on our data and significant published studies from , and mammals, we propose that midgut mitochondria control midgut health and the health of other tissues in vector mosquitoes. Specifically, we argue that trade-offs among resistance to infection, metabolism, lifespan, and reproduction in vector mosquitoes are fundamentally controlled both locally and systemically by midgut mitochondrial function.
在不同的生物体中，各种生理机能受到线粒体功能的深刻调节，线粒体功能由线粒体融合、生物发生、氧化磷酸化（OXPHOS）和线粒体自噬来定义。基于我们的数据以及来自[具体来源未给出]、[具体来源未给出]和哺乳动物的大量已发表研究，我们提出中肠线粒体控制着媒介蚊子中肠的健康以及其他组织的健康。具体而言，我们认为媒介蚊子在抗感染、新陈代谢、寿命和繁殖方面的权衡，从根本上在局部和全身都受到中肠线粒体功能的控制。
