印度拉贾斯坦邦儿童感染 SARS-CoV-2 后病毒清除时间。
Duration of Viral Clearance in Children With SARS-CoV-2 Infection in Rajasthan, India.
机构信息
Department of Pediatrics, SPMCH Institute, SMS Medical College, Jaipur, Rajasthan, India.
Department of Pediatrics, SPMCH Institute, SMS Medical College, Jaipur, Rajasthan, India. Correspondence to: Prof RK Gupta, Department of Pediatric Medicine, SMS Medical College, Jaipur, India.
出版信息
Indian Pediatr. 2021 Feb 15;58(2):123-125. doi: 10.1007/s13312-021-2125-6. Epub 2020 Nov 29.
OBJECTIVE
To study the clinical and laboratory profile and to assess period for viral clearance in COVID 19 children.
METHODS
We reviewed hospital records of children (<18 years) admitted from 1 April to 31 May, 2020 at a tertiary-care public hospital and identified those positive for severe acute respiratory syndrome corona virus (SARS-CoV-2) by RT-PCR of respiratory secretions.
RESULTS
81.2% of the 85 children studied were asymptomatic and 3 (8.5%) died. Severe lymphopenia (43.8%), raised C-reactive protein (93.8%), raised erythrocyte sedimentation rate (75%) and high (>500ng/mL) levels of D-dimer (37.5%) were common. Median (IQR) duration of viral shedding was 7 (5-10) days, with range of 2 to 45 days; 96.3% had viral clearance within 14 days.
CONCLUSIONS
Majority of children aged <18 years with SARS-CoV-2 infection had viral clearance within 14 days.
目的
研究 COVID-19 儿童的临床和实验室特征，并评估病毒清除时间。
方法
我们回顾了 2020 年 4 月 1 日至 5 月 31 日期间在一家三级公立医院住院的<18 岁儿童的住院记录，并通过呼吸道分泌物的 RT-PCR 确定了那些对严重急性呼吸综合征冠状病毒（SARS-CoV-2）呈阳性的儿童。
结果
在研究的 85 名儿童中，81.2%为无症状，3 例（8.5%）死亡。常见的实验室异常包括严重的淋巴细胞减少症（43.8%）、C 反应蛋白升高（93.8%）、红细胞沉降率升高（75%）和 D-二聚体升高（37.5%，>500ng/mL）。病毒脱落的中位数（IQR）持续时间为 7（5-10）天，范围为 2 至 45 天；96.3%的儿童在 14 天内病毒清除。
结论
大多数<18 岁的 SARS-CoV-2 感染儿童在 14 天内清除了病毒。
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