纤溶酶原激活物抑制剂2：佛波酯介导的U-937人组织细胞淋巴瘤细胞分化过程中基因转录的调控
Plasminogen activator inhibitor 2: regulation of gene transcription during phorbol ester-mediated differentiation of U-937 human histiocytic lymphoma cells.
作者信息
Schleuning W D, Medcalf R L, Hession C, Rothenbühler R, Shaw A, Kruithof E K
机构信息
Department of Medicine, University Hospital Center, CHUV, Lausanne, Switzerland.
出版信息
Mol Cell Biol. 1987 Dec;7(12):4564-7. doi: 10.1128/mcb.7.12.4564-4567.1987.
Abstract
We have isolated and sequenced two cDNA clones coding for plasminogen activator inhibitor 2 (PAI-2). The cDNA was used to study the regulation of PAI-2 gene transcription by the tumor-promoting phorbol ester phorbol 12-myristate 13-acetate in the human histiocytic lymphoma cell line U-937. The tumor promoter caused a transient, 50-fold increase of PAI-2 gene transcription.
摘要
我们已经分离并测序了两个编码纤溶酶原激活物抑制剂2（PAI - 2）的cDNA克隆。该cDNA用于研究促肿瘤佛波酯佛波醇12 - 肉豆蔻酸酯13 - 乙酸酯对人组织细胞淋巴瘤细胞系U - 937中PAI - 2基因转录的调控。该肿瘤启动子导致PAI - 2基因转录瞬时增加了50倍。
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