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纤溶酶原激活物抑制剂2：佛波酯介导的U-937人组织细胞淋巴瘤细胞分化过程中基因转录的调控

Plasminogen activator inhibitor 2: regulation of gene transcription during phorbol ester-mediated differentiation of U-937 human histiocytic lymphoma cells.

作者信息

Schleuning W D, Medcalf R L, Hession C, Rothenbühler R, Shaw A, Kruithof E K

机构信息

Department of Medicine, University Hospital Center, CHUV, Lausanne, Switzerland.

出版信息

Mol Cell Biol. 1987 Dec;7(12):4564-7. doi: 10.1128/mcb.7.12.4564-4567.1987.

DOI:10.1128/mcb.7.12.4564-4567.1987
PMID:3325828
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC368144/
Abstract

We have isolated and sequenced two cDNA clones coding for plasminogen activator inhibitor 2 (PAI-2). The cDNA was used to study the regulation of PAI-2 gene transcription by the tumor-promoting phorbol ester phorbol 12-myristate 13-acetate in the human histiocytic lymphoma cell line U-937. The tumor promoter caused a transient, 50-fold increase of PAI-2 gene transcription.

摘要

我们已经分离并测序了两个编码纤溶酶原激活物抑制剂2（PAI - 2）的cDNA克隆。该cDNA用于研究促肿瘤佛波酯佛波醇12 - 肉豆蔻酸酯13 - 乙酸酯对人组织细胞淋巴瘤细胞系U - 937中PAI - 2基因转录的调控。该肿瘤启动子导致PAI - 2基因转录瞬时增加了50倍。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c42a/368144/e6c59abd31ec/molcellb00084-0426-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c42a/368144/e6c59abd31ec/molcellb00084-0426-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c42a/368144/e6c59abd31ec/molcellb00084-0426-a.jpg

相似文献

1
Plasminogen activator inhibitor 2: regulation of gene transcription during phorbol ester-mediated differentiation of U-937 human histiocytic lymphoma cells.纤溶酶原激活物抑制剂2：佛波酯介导的U-937人组织细胞淋巴瘤细胞分化过程中基因转录的调控
Mol Cell Biol. 1987 Dec;7(12):4564-7. doi: 10.1128/mcb.7.12.4564-4567.1987.
2
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Plasminogen activator inhibitor type-1 protein, mRNA and gene transcription are increased by phorbol esters in human rhabdomyosarcoma cells.佛波酯可使人类横纹肌肉瘤细胞中的1型纤溶酶原激活物抑制剂蛋白、信使核糖核酸及基因转录增加。
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Retinoic acid potentiates phorbol ester-mediated induction of urokinase and plasminogen activator inhibitor type 2 in human myeloid leukemic cell lines.维甲酸增强佛波酯介导的人髓系白血病细胞系中尿激酶和纤溶酶原激活物抑制剂2的诱导作用。
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Cell- and gene-specific interactions between signal transduction pathways revealed by okadaic acid. Studies on the plasminogen activating system.冈田酸揭示的信号转导通路之间的细胞和基因特异性相互作用。纤溶酶原激活系统的研究。
J Biol Chem. 1992 Jun 15;267(17):12220-6.

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The transcription factor C/EBP-β mediates constitutive and LPS-inducible transcription of murine SerpinB2.转录因子 C/EBP-β 介导鼠 SerpinB2 的组成型和 LPS 诱导型转录。
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