Department of Toxicology, Tianjin Centers for Disease Control and Prevention, Tianjin, 300011, China.
Department of Toxicology, Tianjin Centers for Disease Control and Prevention, Tianjin, 300011, China.
Regul Toxicol Pharmacol. 2021 Feb;119:104833. doi: 10.1016/j.yrtph.2020.104833. Epub 2020 Nov 28.
A subchronic toxicity study was conducted in Wistar rats to evaluate the potential health effects of genetically modified (GM) herbicide-tolerant soybean DAS-68416-4. Rats were fed with diets containing toasted meal produced from GM soybean engineered with aad-12 and pat genes or containing non-GM soybean at a dose of 30.0, 15.0, or 7.5%,w/w% and 0% (control group) for 90 consecutive days. Animals were evaluated for general behavior, body weight gain, food consumption, food use efficiency, etc. At the middle and end of the study, blood and serum samples were collected for routine and biochemical assays. Internal organs were taken for calculating relative weights and doing histopathological examination. The rats were active and healthy without any abnormal symptoms during the entire study period. No biological differences in hematological or biochemical indices were detected. No histopathological changes were observed. Under the conditions of this study, herbicide-tolerant soybean DAS-68416-4 did not cause any treatment-related effects in Wistar rats following 90 days of dietary administration.
进行了一项亚慢性毒性研究，以评估基因改良（GM）耐除草剂大豆 DAS-68416-4 对健康的潜在影响。Wistar 大鼠喂食含有经 aad-12 和 pat 基因工程改造的 GM 大豆制成的烤豆粕或非 GM 大豆的饲料，剂量分别为 30.0、15.0 或 7.5%（w/w%）和 0%（对照组），连续 90 天。评估动物的一般行为、体重增加、食物消耗、食物利用效率等。在研究的中期和末期，采集血液和血清样本进行常规和生化检测。取内脏器官计算相对重量并进行组织病理学检查。在整个研究期间，大鼠表现活跃且健康，无任何异常症状。未检测到血液学或生化学指标的生物学差异。未观察到组织病理学变化。在本研究条件下，Wistar 大鼠连续 90 天经口给予耐除草剂大豆 DAS-68416-4 后未引起任何与处理相关的影响。
