Department of IT, BIT Sindri, Dhanbad, Jharkhand, 828123, India.
Department of EE, BIT Sindri, Dhanbad, Jharkhand, 828123, India.
Comput Biol Med. 2021 Jan;128:104126. doi: 10.1016/j.compbiomed.2020.104126. Epub 2020 Nov 21.
Genes act in groups known as gene modules, which accomplish different cellular functions in the body. The modular nature of gene networks was used in this study to detect functionally enriched modules in samples obtained from COPD patients. We analyzed modules extracted from COPD samples and identified crucial genes associated with the disease COVID-19. We also extracted modules from a COVID-19 dataset and analyzed a suspected set of genes that may be associated with this deadly disease. We used information available for two other viruses that cause SARS and MERS because their physiology is similar to that of the COVID-19 virus. We report several crucial genes associated with COVID-19: RPA2, POLD4, MAPK8, IRF7, JUN, NFKB1, NFKBIA, CD40LG, FASLG, ICAM1, LIFR, STAT2 and CCR1. Most of these genes are related to the immune system and respiratory organs, which emphasizes the fact that COPD weakens this system and makes patients more susceptible to developing severe COVID-19.
基因在称为基因模块的群组中发挥作用，这些模块在体内完成不同的细胞功能。本研究利用基因网络的模块化性质来检测从 COPD 患者样本中获得的功能丰富的模块。我们分析了从 COPD 样本中提取的模块，并确定了与 COVID-19 疾病相关的关键基因。我们还从 COVID-19 数据集提取模块，并分析了一组疑似与这种致命疾病相关的基因。我们使用了两种其他引起 SARS 和 MERS 的病毒的可用信息，因为它们的生理机能与 COVID-19 病毒相似。我们报告了与 COVID-19 相关的几个关键基因：RPA2、POLD4、MAPK8、IRF7、JUN、NFKB1、NFKBIA、CD40LG、FASLG、ICAM1、LIFR、STAT2 和 CCR1。这些基因大多与免疫系统和呼吸道器官有关，这强调了 COPD 削弱免疫系统并使患者更容易患上严重 COVID-19 的事实。
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