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连续十天用葡萄籽原花青素处理雌性大鼠可长期预防某些衰老过程。

A Ten-Day Grape Seed Procyanidin Treatment Prevents Certain Ageing Processes in Female Rats over the Long Term.

机构信息

MoBioFood Research Group, Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, 43007 Tarragona, Spain.

出版信息

Nutrients. 2020 Nov 27;12(12):3647. doi: 10.3390/nu12123647.

DOI:10.3390/nu12123647
PMID:33260866
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7759988/
Abstract

Adaptive homeostasis declines with age and this leads to, among other things, the appearance of chronic age-related pathologies such as cancer, neurodegeneration, osteoporosis, sarcopenia, cardiovascular disease and diabetes. Grape seed-derived procyanidins (GSPE) have been shown to be effective against several of these pathologies, mainly in young animal models. Here we test their effectiveness in aged animals: 21-month-old female rats were treated with 500 mg GSPE/kg of body weight for ten days. Afterwards they were kept on a chow diet for eleven weeks. Food intake, body weight, metabolic plasma parameters and tumor incidence were measured. The GSPE administered to aged rats had an effect on food intake during the treatment and after eleven weeks continued to have an effect on visceral adiposity. It prevented pancreas dysfunction induced by ageing and maintained a higher glucagon/insulin ratio together with a lower decrease in ketonemia. It was very effective in preventing age-related tumor development. All in all, this study supports the positive effect of GSPE on preventing some age-related pathologies.

摘要

适应性体内平衡随着年龄的增长而下降，这导致了许多慢性与年龄相关的病理，如癌症、神经退行性疾病、骨质疏松症、肌肉减少症、心血管疾病和糖尿病。葡萄籽原花青素（GSPE）已被证明对这些病理中的几种有效，主要在年轻的动物模型中。在这里，我们在老年动物中测试它们的有效性：21 个月大的雌性大鼠用 500 毫克 GSPE/公斤体重治疗 10 天。之后，它们继续在标准饮食中喂养 11 周。测量食物摄入量、体重、代谢血浆参数和肿瘤发生率。给予老年大鼠的 GSPE 在治疗期间和 11 周后对食物摄入量有影响，并且继续对内脏肥胖有影响。它可以预防衰老引起的胰腺功能障碍，并保持较高的胰高血糖素/胰岛素比值，同时降低酮血症的下降。它在预防与年龄相关的肿瘤发展方面非常有效。总之，这项研究支持 GSPE 对预防一些与年龄相关的病理的积极作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c05/7759988/0df338772c6b/nutrients-12-03647-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c05/7759988/6c74c2c6751a/nutrients-12-03647-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c05/7759988/545b0f536b84/nutrients-12-03647-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c05/7759988/e759574a9940/nutrients-12-03647-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c05/7759988/2549830f607e/nutrients-12-03647-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c05/7759988/0df338772c6b/nutrients-12-03647-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c05/7759988/6c74c2c6751a/nutrients-12-03647-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c05/7759988/545b0f536b84/nutrients-12-03647-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c05/7759988/e759574a9940/nutrients-12-03647-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c05/7759988/2549830f607e/nutrients-12-03647-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c05/7759988/0df338772c6b/nutrients-12-03647-g005.jpg

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