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大麻素受体相互作用蛋白 1a(CRIP1a)在健康和疾病中的作用。

Cannabinoid Receptor Interacting Protein 1a (CRIP1a) in Health and Disease.

机构信息

Department of Physiology and Pharmacology, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC 20157, USA.

Department of Biochemistry and Center for Structural Biology, Wake Forest School of Medicine, Winston-Salem, NC 20157, USA.

出版信息

Biomolecules. 2020 Nov 27;10(12):1609. doi: 10.3390/biom10121609.

DOI:10.3390/biom10121609
PMID:33261012
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7761089/
Abstract

Endocannabinoid signaling depends upon the CB and CB cannabinoid receptors, their endogenous ligands anandamide and 2-arachidonoylglycerol, and intracellular proteins that mediate responses via the C-terminal and other intracellular receptor domains. The CB receptor regulates and is regulated by associated G proteins predominantly of the Gi/o subtypes, β-arrestins 1 and 2, and the cannabinoid receptor-interacting protein 1a (CRIP1a). Evidence for a physiological role for CRIP1a is emerging as data regarding the cellular localization and function of CRIP1a are generated. Here we summarize the neuronal distribution and role of CRIP1a in endocannabinoid signaling, as well as discuss investigations linking CRIP1a to development, vision and hearing sensory systems, hippocampus and seizure regulation, and psychiatric disorders including schizophrenia. We also examine the genetic and epigenetic association of CRIP1a within a variety of cancer subtypes. This review provides evidence upon which to base future investigations on the function of CRIP1a in health and disease.

摘要

内源性大麻素信号依赖于 CB 和 CB1 大麻素受体、它们的内源性配体花生四烯酸乙醇胺和 2-花生四烯酰甘油,以及通过 C 末端和其他细胞内受体结构域介导反应的细胞内蛋白。CB 受体通过主要属于 Gi/o 亚型的相关 G 蛋白、β-抑制蛋白 1 和 2 以及大麻素受体相互作用蛋白 1a(CRIP1a)进行调节和被调节。随着关于 CRIP1a 的细胞定位和功能的数据的产生,CRIP1a 发挥生理作用的证据正在出现。在这里,我们总结了 CRIP1a 在内源性大麻素信号中的神经元分布和作用,并讨论了将 CRIP1a 与发育、视觉和听觉感觉系统、海马体和癫痫调节以及包括精神分裂症在内的精神疾病联系起来的研究。我们还检查了 CRIP1a 在各种癌症亚型中的遗传和表观遗传关联。本综述提供了基于 CRIP1a 在健康和疾病中的功能进行未来研究的证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c948/7761089/6cfd9fcd129a/biomolecules-10-01609-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c948/7761089/e25b91521dc4/biomolecules-10-01609-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c948/7761089/6cfd9fcd129a/biomolecules-10-01609-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c948/7761089/e25b91521dc4/biomolecules-10-01609-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c948/7761089/6cfd9fcd129a/biomolecules-10-01609-g005.jpg

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9
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