Baughn R E
Department of Microbiology and Immunology, Baylor College of Medicine, Houston, Texas.
Rev Infect Dis. 1987 Jul-Aug;9 Suppl 4:S372-85. doi: 10.1093/clinids/9.supplement_4.s372.
In recent years studies concerned with the attachment of Treponema pallidum to host cells have focused on the possible, role of fibronectin in mediation of this event. Although our understanding of in vitro fibronectin-T. pallidum interactions has increased markedly, considerable controversy exists concerning not only the kinetics of binding but whether fibronectin is the only matrix protein involved in attachment. Moreover, a unifying hypothesis concerned with the role of fibronectin in the pathogenesis of syphilis cannot be limited solely to early events. Further characterization of fibronectin-T. pallidum interactions must also take into consideration that the natural infection, characterized by distinct stages, is accompanied by immunologic responses that undoubtedly impact on those cellular interactions.
近年来，有关梅毒螺旋体与宿主细胞附着的研究聚焦于纤连蛋白在介导这一过程中可能发挥的作用。尽管我们对体外纤连蛋白与梅毒螺旋体相互作用的理解有了显著提高，但不仅在结合动力学方面存在相当大的争议，而且对于纤连蛋白是否是参与附着的唯一基质蛋白也存在争议。此外，关于纤连蛋白在梅毒发病机制中作用的统一假说不能仅仅局限于早期事件。对纤连蛋白与梅毒螺旋体相互作用的进一步表征还必须考虑到，以不同阶段为特征的自然感染伴随着免疫反应，而这些免疫反应无疑会影响那些细胞间相互作用。
