Medical School of Chinese PLA, Beijing, 100842, China.
Department of Infectious Diseases, the Fifth Medical Centre of Chinese PLA General Hospital, National Clinical Research Centre for Infectious Diseases, Beijing, 100039, China.
Mil Med Res. 2020 Dec 1;7(1):59. doi: 10.1186/s40779-020-00288-y.
On October 5th, 2020, Drs. Harvey J. Alter, Michael Houghton and Charles M. Rice were rewarded with Nobel Prize in Physiology or Medicine for "the discovery of hepatitis C virus (HCV)". During the past 50 years, remarkable achievements have been made in treatment of HCV infection: it has changed from being a life-threatening chronic disease to being curable. In this commentary, we briefly summarized the milestone events in the "scientific journey" from the first report of non-A, non-B hepatitis and discovery of the pathogen (HCV) to final identification of efficacious direct-acting antivirals. Further, we address the challenges and unmet issues in this field.
2020 年 10 月 5 日，哈维·J·阿尔特、迈克尔·霍顿和查尔斯·M·赖斯三位博士因“发现丙型肝炎病毒（HCV）”而获得诺贝尔生理学或医学奖。在过去的 50 年里，丙型肝炎病毒感染的治疗取得了显著的成就：它已经从一种危及生命的慢性疾病转变为可治愈的疾病。在这篇评论中，我们简要总结了从首次报道非甲非乙型肝炎和发现病原体（HCV）到最终确定有效直接作用抗病毒药物的“科学之旅”中的里程碑事件。此外，我们还讨论了该领域的挑战和未满足的需求。
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