Hagymási Krisztina
1st Department of Surgery and Interventional Gastroenterology, Semmelweis University, Budapest, Hungary.
Struct Chem. 2021;32(2):909-913. doi: 10.1007/s11224-021-01731-z. Epub 2021 Feb 9.
At the time of COVID-19 coronavirus pandemia, the Nobel Prize of Physiology or Medicine 2020 was awarded jointly to three researchers Harvey J. Alter, Charles M. Rice, and Michael Houghton for the discovery of Hepatitis C virus. Their works contributed to the isolation of the blood-borne virus, causing chronic hepatitis in 80% of infected person, resulting in cirrhosis, and in elevated risk of liver failure and hepatocellular carcinoma formation. Their results created the basis of HCV screening of blood, and blood products, achieving more than 95% cure of infected people without nearly side effects with direct-acting antiviral agents, supporting the goal of the WHO targeting the elimination of viral hepatitis by 2030.
在新冠病毒大流行期间，2020年诺贝尔生理学或医学奖共同授予了三位研究人员哈维·J·阿尔特、查尔斯·M·赖斯和迈克尔·霍顿，以表彰他们发现丙型肝炎病毒。他们的工作促成了这种血源性病毒的分离，该病毒会使80%的感染者患上慢性肝炎，进而导致肝硬化，并增加肝衰竭和肝细胞癌形成的风险。他们的研究成果为丙型肝炎病毒血液及血液制品筛查奠定了基础，使用直接抗病毒药物可使超过95%的感染者治愈且几乎无副作用，支持了世界卫生组织到2030年消除病毒性肝炎的目标。
