Liver Diseases Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI.
Hepatology. 2021 Nov;74(5):2813-2823. doi: 10.1002/hep.31830. Epub 2021 Oct 5.
The 2020 Nobel Prize in Medicine or Physiology was awarded to Drs. Harvey Alter, Michael Houghton, and Charles Rice for their contributions to the discovery and characterization of the hepatitis C virus (HCV). Their achievements represent a remarkable triumph of biomedical science which allowed the development of curative therapy for HCV, that will save countless lives. This tribute provides a historical perspective of the laureates' seminal work leading to the discovery of the HCV and a synopsis of a forum hosted by the American Association for the Study of Liver Diseases to honor the laureates in which they offered their perspectives, advice for young investigators and what's left to accomplish in the field. Finally, others in the research community who have worked closely with one or more of the laureates, share some of their personal reflections and anecdotes.
2020 年诺贝尔生理学或医学奖授予哈维·J·阿尔特（Harvey J. Alter）、迈克尔·霍顿（Michael Houghton）和查尔斯·M·赖斯（Charles M. Rice），以表彰他们在发现丙型肝炎病毒（HCV）方面的贡献。他们的成就代表了生物医学科学的一项非凡胜利，使得 HCV 的治疗方法得以发展，挽救了无数生命。本文从历史角度回顾了获奖者发现 HCV 的开创性工作，并简述了美国肝病研究协会主办的一个论坛，以向获奖者致敬，他们在论坛上分享了自己的观点、对年轻研究人员的建议以及该领域有待完成的工作。最后，与获奖者之一或多位获奖者密切合作的研究界的其他人也分享了一些个人的反思和轶事。
