Universidade Federal Fluminense, Departamento de Química Orgânica, Instituto de Química, Campus do Valonguinho, CEP 24020-150 Niterói, RJ, Brazil.
Universidade Federal Fluminense, Departamento de Química Orgânica, Instituto de Química, Campus do Valonguinho, CEP 24020-150 Niterói, RJ, Brazil.
Bioorg Chem. 2021 Jan;106:104488. doi: 10.1016/j.bioorg.2020.104488. Epub 2020 Nov 19.
In December 2019, a new variant of SARS-CoV emerged, the so-called acute severe respiratory syndrome coronavirus 2 (SARS-CoV-2). This virus causes the new coronavirus disease (COVID-19) and has been plaguing the world owing to its unprecedented spread efficiency, which has resulted in a huge death toll. In this sense, the repositioning of approved drugs is the fastest way to an effective response to a pandemic outbreak of this scale. Considering these facts, in this review we provide a comprehensive and critical discussion on the chemical aspects surrounding the drugs currently being studied as candidates for COVID-19 therapy. We intend to provide the general chemical community with an overview on the synthetic/biosynthetic pathways related to such molecules, as well as their mechanisms of action against the evaluated viruses and some insights on the pharmacological interactions involved in each case. Overall, the review aims to present the chemical aspects of the main bioactive molecules being considered to be repositioned for effective treatment of COVID-19 in all phases, from the mildest to the most severe.
2019 年 12 月，一种新型的严重急性呼吸系统综合征冠状病毒（SARS-CoV）出现，即所谓的急性严重呼吸系统综合征冠状病毒 2（SARS-CoV-2）。这种病毒会引起新型冠状病毒病（COVID-19），由于其前所未有的传播效率，该病毒一直在肆虐全球，导致了巨大的死亡人数。从这个意义上说，重新定位已批准的药物是对这种规模的大流行爆发做出有效反应的最快途径。考虑到这些事实，在这篇综述中，我们对目前作为 COVID-19 治疗候选药物进行研究的药物的化学方面进行了全面和批判性的讨论。我们旨在为广大化学界提供有关这些分子的合成/生物合成途径的概述，以及它们针对评估的病毒的作用机制，以及每种情况下涉及的药理学相互作用的一些见解。总的来说，该综述旨在介绍正在考虑重新定位以有效治疗 COVID-19 的主要生物活性分子的化学方面，涵盖从最轻微到最严重的所有阶段。
