Diabetes Research Centre, University of Leicester, Leicester, UK.
NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
BMJ Open Diabetes Res Care. 2020 Dec;8(2). doi: 10.1136/bmjdrc-2020-001359.
Trimethylamine -oxide (TMAO) has been identified as a novel gut-derived molecule that is associated with the risk of cardiometabolic diseases. However, the relationship between TMAO and physical activity is not well understood. This study prospectively investigates the association between TMAO and objectively assessed physical activity in a population at high risk of type 2 diabetes mellitus.
Baseline and 12-month follow-up data were used from the Walking Away from Type 2 Diabetes trial, which recruited adults at high risk of type 2 diabetes from primary care in 2009-2010. TMAO was analyzed using targeted mass spectrometry. Generalized estimating equation models with an exchangeable correlation structure were used to investigate the associations between accelerometer-assessed exposures (sedentary time, light physical activity, moderate to vigorous physical activity (MVPA)) and TMAO, adjusting for demographic, clinical and lifestyle factors in varying degrees.
Overall, 483 individuals had plasma samples available for the analysis of TMAO (316 (65.4%) men, 167 (34.6%) women), contributing 886 observations to the analysis. MVPA (min/day) was associated with TMAO in all models. In the fully adjusted model, each 30 min or SD difference in MVPA was associated with 0.584 μmol/L (0.070, 1.098) and 0.456 μmol/L (0.054, 0.858) lower TMAO, respectively. Sedentary time and light physical activity were not associated with TMAO in any model.
Engagement with MVPA was associated with lower TMAO levels, suggesting a possible new mechanism underlining the inverse relationship between physical activity and cardiometabolic health.
氧化三甲胺（TMAO）已被确定为一种新型的肠道来源分子，与心血管代谢疾病的风险相关。然而，TMAO 与体力活动之间的关系尚不清楚。本研究前瞻性调查了高 2 型糖尿病风险人群中 TMAO 与客观评估的体力活动之间的关系。
使用 2009-2010 年从初级保健中招募的高 2 型糖尿病风险成年人的“远离 2 型糖尿病”试验的基线和 12 个月随访数据。使用靶向质谱法分析 TMAO。使用具有可交换相关结构的广义估计方程模型，调整不同程度的人口统计学、临床和生活方式因素，调查加速度计评估的暴露（久坐时间、低强度体力活动、中等到剧烈体力活动（MVPA））与 TMAO 之间的关联。
总体而言，483 名个体有血浆样本可用于 TMAO 分析（316（65.4%）男性，167（34.6%）女性），共有 886 个观察值用于分析。在所有模型中，MVPA（分钟/天）与 TMAO 相关。在完全调整的模型中，MVPA 每增加 30 分钟或 SD，TMAO 分别降低 0.584 μmol/L（0.070，1.098）和 0.456 μmol/L（0.054，0.858）。在任何模型中，久坐时间和低强度体力活动与 TMAO 均无关。
参与 MVPA 与较低的 TMAO 水平相关，这表明体力活动与心血管代谢健康之间的反比关系可能存在新的机制。
