对巨噬细胞在角叉菜胶诱导的免疫抑制中作用的重新评估。
A re-evaluation of the role of macrophages in carrageenan-induced immunosuppression.
作者信息
Rumjanek V M, Watson S R, Sljivić V S
出版信息
Immunology. 1977 Sep;33(3):423-32.
Abstract
Administration of a single dose of 1 mg carrageenan to mice cause a temporary blockade of hepatic phagocytosis of 51Cr-labelled sheep erythrocytes (SRBC) and a prolonged reduction in the number of splenic plaque-forming cells (PFC) against SRBC. The in vitro responses to phytohaemagglutinin (PHA) and SRBC were also suppressed, whereas the response to the T cell-independent antigen DNP-Ficoll was not affected. Other in vitro experiments have shown that responses of normal cells can be actively suppressed by macrophages from carrageenan-treated mice and the possible mechanisms of this suppression are discussed.
摘要
给小鼠单次注射1毫克角叉菜胶会导致对51Cr标记的绵羊红细胞（SRBC）的肝脏吞噬作用暂时受阻，以及针对SRBC的脾斑块形成细胞（PFC）数量长期减少。对植物血凝素（PHA）和SRBC的体外反应也受到抑制，而对T细胞非依赖性抗原DNP-菲可的反应不受影响。其他体外实验表明，来自角叉菜胶处理小鼠的巨噬细胞可主动抑制正常细胞的反应，并对这种抑制的可能机制进行了讨论。
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