Fowler E F, Thomson A W
Br J Exp Pathol. 1978 Apr;59(2):213-9.
Injection of 5 mg carrageenan caused hepatosplenomegaly and thymic involution and resulted in temporary blockade of the mononuclear phagocyte system (MPS). Impaired MPS activity was shown by decreased hepatic phagocytosis of i.v. injected colloidal carbon and 51Cr-labelled sheep red blood cells (SRBC). Depression of Kupffer cell activity was dependent on carrageenan dose, route of administration and interval between carrageenan and particle injection. Reduction in hepatic uptake of SRBC was accompanied by increased localization of these cells within the spleen.
注射5毫克角叉菜胶会导致肝脾肿大和胸腺萎缩，并导致单核吞噬细胞系统（MPS）暂时受阻。静脉注射胶体碳和51铬标记的绵羊红细胞（SRBC）后，肝脏吞噬作用降低，表明MPS活性受损。枯否细胞活性的降低取决于角叉菜胶的剂量、给药途径以及角叉菜胶与颗粒注射之间的间隔时间。肝脏对SRBC摄取的减少伴随着这些细胞在脾脏中定位的增加。
