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刺激和阻断小鼠单核吞噬细胞系统对其足垫迟发型反应（针对绵羊红细胞）的影响。

Effect of stimulation and blockade of mononuclear phagocyte system on the delayed footpad reaction to SRBC in mice.

作者信息

Yoshikai Y, Miake S, Matsumoto T, Nomoto K, Takeya K

出版信息

Immunology. 1979 Nov;38(3):577-83.

PMID:521054
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1457816/
Abstract

The delayed footpad reaction to sheep erythrocytes (SRBC) was studied in mice whose mononuclear phagocyte system (MPS) was blocked or stimulated. Colloidal carbon or carrageenan was used for the blockade of MPS and Corynebacterium parvum or diethylstilbestrol used for the stimulation. The optimal dose of SRBC for the induction of the delayed footpad reaction was lower in MPS-blocked mice than in non-treated mice, whereas a high dose of SRBC was required for the induction of the strongest delayed footpad reaction in MPS-stimulated mice. These results suggest that non-specific phagocytic function of MPS modulates subsequent immune responses after administration of antigens.

摘要

在单核吞噬细胞系统（MPS）被阻断或刺激的小鼠中，研究了对绵羊红细胞（SRBC）的迟发性足垫反应。用胶体碳或角叉菜胶阻断MPS，用短小棒状杆菌或己烯雌酚刺激MPS。诱导迟发性足垫反应的SRBC最佳剂量在MPS阻断的小鼠中比未处理的小鼠低，而在MPS刺激的小鼠中诱导最强迟发性足垫反应需要高剂量的SRBC。这些结果表明，MPS的非特异性吞噬功能在给予抗原后调节随后的免疫反应。

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本文引用的文献

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The role of the reticuloendothelial system in the host reaction to neoplasia.网状内皮系统在宿主对肿瘤形成的反应中的作用。
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THE SUPPRESSIVE ROLE OF MOUSE PERITONEAL PHAGOCYTES IN AGGLUTININ RESPONSE.小鼠腹腔吞噬细胞在凝集素反应中的抑制作用
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Quantitative study of the granulopectic activity of the reticulo-endothelial system. II. A study of the kinetics of the R. E. S. in relation to the dose of carbon injected; relationship between the weight of the organs and their activity.网状内皮系统粒细胞吞噬活性的定量研究。II. 网状内皮系统动力学与注入碳剂量的关系；器官重量与其活性之间的关系。
Br J Exp Pathol. 1953 Aug;34(4):441-57.
6
Stimulation of splenic antigen uptake and of antibody response in mice by India ink or other "blockading" agents.印度墨水或其他“阻断”剂对小鼠脾脏抗原摄取及抗体反应的刺激作用。
Immunology. 1966 Aug;11(2):127-36.
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Effects of RES "blockade" on antibody-formation. I. Suppressed cellular and humoral haemolysin responses in mice injected with carbon particles.白藜芦醇“阻断”对抗体形成的影响。I. 对注射碳颗粒的小鼠细胞和体液溶血素反应的抑制作用
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