Zhu Tianhao, Bao Xunxia, Chen Mingyu, Lin Rui, Zhuyan Jianan, Zhen Timing, Xing Kaichen, Zhou Wei, Zhu Sibo
School of Life Sciences, Fudan University, Shanghai, China.
Shanghai Starriver Bilingual School, Shanghai, China.
Front Oncol. 2020 Nov 11;10:585284. doi: 10.3389/fonc.2020.585284. eCollection 2020.
Lung cancer, renowned for its fast progression and metastatic potency, is rising to become a leading cause of death globally. It has been long observed that lung cancer is particularly ept in spawning distant metastasis at its early stages, and it can readily colonize virtually any human organ. In recent years, cancer research has shed light on why lung cancer is endowed with its exceptional ability to metastasize. In this review, we will take a comprehensive look at the current research on lung cancer metastasis, including molecular pathways, anatomical features and genetic traits that make lung cancer intrinsically metastatic, as we go from lung cancer's general metastatic potential to the particular metastasis mechanisms in multiple organs. We highly concerned about the advanced discovery and development of lung cancer metastasis, indicating the importance of lung cancer specific gene mutations, heterogeneity or biomarker discovery, and discussing potential opportunities and challenges. We will also introduce some current treatments that targets certain metastatic strategies of non-small cell lung cancer (NSCLC). Advances made in these regards could be critical to our current knowledge base of lung cancer metastasis.
肺癌以其快速进展和转移能力而闻名，正逐渐成为全球主要的死亡原因。长期以来人们观察到，肺癌尤其易于在早期阶段发生远处转移，并且它几乎可以轻易地在人体任何器官中定植。近年来，癌症研究揭示了肺癌为何具有其特殊的转移能力。在这篇综述中，我们将全面审视目前关于肺癌转移的研究，包括从肺癌的一般转移潜能到多个器官中的特定转移机制，那些使肺癌具有内在转移性的分子途径、解剖学特征和遗传特性。我们高度关注肺癌转移的前沿发现和进展，指出肺癌特异性基因突变、异质性或生物标志物发现的重要性，并讨论潜在的机遇和挑战。我们还将介绍一些目前针对非小细胞肺癌（NSCLC）特定转移策略的治疗方法。在这些方面取得的进展对于我们目前关于肺癌转移的知识库可能至关重要。
