长期暴露于链球菌磷壁酸后兔肾中肾钙质沉着症的诱发
Induction of nephrocalcinosis in rabbit kidneys after long-term exposure to a streptococcal teichoic acid.
作者信息
Waltersdorff R L, Fiedel B A, Jackson R W
出版信息
Infect Immun. 1977 Sep;17(3):665-7. doi: 10.1128/iai.17.3.665-667.1977.
Abstract
New Zealand white rabbits were administered soluble lipoteichoic acid from Streptococcus pyogenes 1-RP41 on alternate days for up to 30 days. An increased incidence of renal cortico-medullary calculi was observed after day 21; the use of fluorescent-labeled anti-teichoic acid antibody located teichoic acid predominantly in the cortical-associated tubules.
摘要
给新西兰白兔每隔一天注射化脓性链球菌1-RP41的可溶性脂磷壁酸，持续30天。在第21天后观察到肾皮质-髓质结石的发病率增加；使用荧光标记的抗磷壁酸抗体发现磷壁酸主要位于与皮质相关的肾小管中。
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