Schneeweiss U, Schmidt W, Fabricius E M
Central Institute of Cancer Research, Academy of Sciences of the GDR.
Zentralbl Bakteriol Mikrobiol Hyg A. 1987 Oct;266(3-4):506-21. doi: 10.1016/s0176-6724(87)80233-x.
When investigating tetanus lethality summation curves of mice under comparable quantitative conditions following a temporarily limited administration of penicillin, the curves obtained can be calculated by the kinetics of tumour cells or wound fibroblasts. In particular, it has been shown that the optimal efficacy of penicillin, after short-time usage as compared with a long-time administration schedule, is determined by the generation time of the tetanus rods as a function of the mitotic cycle of the "pace-making" tumour cells or wound fibroblasts. Further variables of the mathematical model imply the pharmacokinetics of penicillin and the recovery process of the "hit" tetanus rods. From these results some basic experimental and clinical tetanus issues can be elucidated; thus, the mitosis theory of tetanus is being verified for the stage of incubation and of clinical manifestation, while the classical necrosis theory of the pathogenesis of tetanus infection should be valid only for the final stage.
在对小鼠进行破伤风致死性总和曲线研究时，在青霉素临时有限给药后的可比定量条件下，所获得的曲线可通过肿瘤细胞或伤口成纤维细胞的动力学来计算。特别是，已表明与长期给药方案相比，短期使用青霉素后的最佳疗效取决于破伤风杆菌的世代时间，该时间是“起搏”肿瘤细胞或伤口成纤维细胞有丝分裂周期的函数。数学模型的其他变量意味着青霉素的药代动力学和“命中”破伤风杆菌的恢复过程。从这些结果可以阐明一些基本的实验性和临床性破伤风问题；因此，破伤风的有丝分裂理论在潜伏期和临床表现期得到了验证，而破伤风感染发病机制的经典坏死理论仅在最后阶段有效。
