Krohova Jana, Faes Luca, Czippelova Barbora, Turianikova Zuzana, Mazgutova Nikoleta, Pernice Riccardo, Busacca Alessandro, Marinazzo Daniele, Stramaglia Sebastiano, Javorka Michal
Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 03601 Martin, Slovakia.
Department of Physiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 03601 Martin, Slovakia.
Entropy (Basel). 2019 May 24;21(5):526. doi: 10.3390/e21050526.
Heart rate variability (HRV; variability of the RR interval of the electrocardiogram) results from the activity of several coexisting control mechanisms, which involve the influence of respiration (RESP) and systolic blood pressure (SBP) oscillations operating across multiple temporal scales and changing in different physiological states. In this study, multiscale information decomposition is used to dissect the physiological mechanisms related to the genesis of HRV in 78 young volunteers monitored at rest and during postural and mental stress evoked by head-up tilt (HUT) and mental arithmetics (MA). After representing RR, RESP and SBP at different time scales through a recently proposed method based on multivariate state space models, the joint information transfer T RESP , SBP → RR is decomposed into unique, redundant and synergistic components, describing the strength of baroreflex modulation independent of respiration ( U SBP → RR ), nonbaroreflex ( U RESP → RR ) and baroreflex-mediated ( R RESP , SBP → RR ) respiratory influences, and simultaneous presence of baroreflex and nonbaroreflex respiratory influences ( S RESP , SBP → RR ), respectively. We find that fast (short time scale) HRV oscillations-respiratory sinus arrhythmia-originate from the coexistence of baroreflex and nonbaroreflex (central) mechanisms at rest, with a stronger baroreflex involvement during HUT. Focusing on slower HRV oscillations, the baroreflex origin is dominant and MA leads to its higher involvement. Respiration influences independent on baroreflex are present at long time scales, and are enhanced during HUT.
心率变异性（HRV；心电图RR间期的变异性）源于多种共存控制机制的活动，这些机制涉及呼吸（RESP）和收缩压（SBP）振荡的影响，它们在多个时间尺度上起作用，并在不同生理状态下发生变化。在本研究中，多尺度信息分解被用于剖析78名年轻志愿者在静息状态以及由头高位倾斜（HUT）和心算（MA）诱发的姿势和精神应激期间与HRV产生相关的生理机制。通过一种基于多元状态空间模型的最新方法在不同时间尺度上表示RR、RESP和SBP后，联合信息传递T RESP,SBP→RR被分解为独特、冗余和协同成分，分别描述独立于呼吸的压力反射调制强度（U SBP→RR）、非压力反射（U RESP→RR）和压力反射介导（R RESP,SBP→RR）的呼吸影响，以及压力反射和非压力反射呼吸影响的同时存在（S RESP,SBP→RR）。我们发现，快速（短时间尺度）HRV振荡——呼吸性窦性心律不齐——在静息状态下源于压力反射和非压力反射（中枢）机制的共存，在HUT期间压力反射的参与更强。关注较慢的HRV振荡，压力反射起源占主导，MA导致其参与度更高。独立于压力反射的呼吸影响在长时间尺度上存在，并且在HUT期间增强。
