School of Nursing, 6614University of Pittsburgh, PA, USA.
Biol Res Nurs. 2021 Jul;23(3):394-401. doi: 10.1177/1099800420975205. Epub 2020 Dec 3.
Incorporating omics into non-pharmacological intervention research design could provide a better understanding of the variability in response to these interventions. It would also provide evidence for precision-based non-pharmacological interventions, including interventions focused on symptoms. The purpose of this manuscript was to present examples of studies that have used omics to examine response to non-pharmacological intervention. Using the interventions of exercise, diet (related to obesity), cognitive based therapy, and alternative mind-body practices (meditation, yoga, and tai chi), PubMed was searched to identify studies that incorporated genomic or other omic approaches as part of a non-pharmacological intervention. The review identified genes associated with the effectiveness of each of the interventions. Although there were no genes that were associated with all four interventions, there were nine genes that were the focus of more than one intervention (). All nine of these genes were either directly or indirectly biologically related to one another, suggesting that this cadre of genes could serve as an initiation point for investigations using omic approaches to better understand response to non-pharmacological interventions.
将组学纳入非药物干预研究设计中，可以更好地了解这些干预措施的反应变异性。它还为基于精准的非药物干预提供了证据，包括针对症状的干预措施。本文的目的是展示使用组学研究来检验非药物干预反应的研究示例。使用运动、饮食（与肥胖相关）、认知为基础的治疗和替代身心实践（冥想、瑜伽和太极）等干预措施，在 PubMed 上进行了检索，以确定将基因组或其他组学方法作为非药物干预一部分的研究。该综述确定了与每种干预措施有效性相关的基因。尽管没有与所有四种干预措施都相关的基因，但有九个基因是多个干预措施的重点（）。这九个基因要么直接要么间接地相互之间具有生物学关系，这表明这一组基因可以作为使用组学方法更好地了解非药物干预反应的起始点。
