Institute of Biochemistry and Molecular Biology, Faculty of Medicine, University of Bonn, Bonn, Germany.
EMBO Rep. 2020 Dec 3;21(12):e51830. doi: 10.15252/embr.202051830.
Mitochondrial respiratory chain complexes associate in supercomplexes, but the physiological role of these assemblies remains controversial. Recent studies in EMBO Reports reveal that supercomplexes promote metabolic fitness. Berndtsson et al (2020) demonstrate that supercomplex formation enhances electron transport by reducing the distance for diffusion of cytochrome c between cytochrome bc complex and cytochrome c oxidase and thereby increases competitive fitness in yeast. Similarly, Garcia-Poyatos et al (2020) report that zebrafish lacking the supercomplex assembly factor SCAF1 display a reduced growth and decreased female fertility.
线粒体呼吸链复合物在超复合物中相互关联，但这些组装体的生理作用仍存在争议。最近在《欧洲分子生物学组织报告》上的研究揭示了超复合物促进代谢适应性的作用。Berndtsson 等人（2020）证明，超复合物的形成通过减少细胞色素 c 在细胞色素 bc 复合物和细胞色素 c 氧化酶之间扩散的距离来增强电子传递，从而提高了酵母的竞争适应性。同样，Garcia-Poyatos 等人（2020）报道说，缺乏超复合物组装因子 SCAF1 的斑马鱼表现出生长减少和雌性生育力降低。
