Graduate Program in Obstetrics, Gynecology and Mastology, Botucatu Medical School, São Paulo State University/Unesp, São Paulo, Brazil.
Department of Gynecology and Obstetrics, Botucatu Medical School, São Paulo State University/Unesp, Botucatu, SP, Brazil.
Sci Rep. 2020 Dec 3;10(1):21042. doi: 10.1038/s41598-020-78099-3.
The aim was to assess the role of Metabolic Syndrome (MetS) diagnostic markers, recommended by three different guidelines, in the prediction of hyperglycemia in pregnancy. This cross-sectional cohort study included 506 non-diabetic women, with a singleton pregnancy, who underwent a diagnostic test for hyperglycemia at 24-28 weeks. Clinical, anthropometric, and laboratory data were obtained. The relationship between MetS markers and the risk of hyperglycemia was evaluated by backward stepwise logistic regression analysis (OR, 95% CI). The limit of statistical significance was 95% (p < 0.05). Triglycerides (TG) ≥ 150 mg/dL, blood pressure (BP) ≥ 130/85 mmHg, fasting glucose (FG) ≥ 100 mg/dL, and waist circumference (WC) > 88 cm were identified as independent risk factors for hyperglycemia in pregnancy. These results might help the selective screening of hyperglycemia in pregnancy.
目的是评估三种不同指南推荐的代谢综合征（MetS）诊断标志物在预测妊娠期间高血糖中的作用。本横断面队列研究纳入了 506 例无糖尿病的单胎妊娠女性，她们在 24-28 周时接受了高血糖诊断性检查。获取了临床、人体测量学和实验室数据。采用向后逐步逻辑回归分析（OR，95%CI）评估 MetS 标志物与高血糖风险之间的关系。统计显著性界限为 95%（p<0.05）。甘油三酯（TG）≥150mg/dL、血压（BP）≥130/85mmHg、空腹血糖（FG）≥100mg/dL 和腰围（WC）>88cm 被确定为妊娠期间高血糖的独立危险因素。这些结果可能有助于选择性筛查妊娠期间的高血糖。
